For research use only. Not for therapeutic Use.
FN-1501（Cat No.:I020238）is a novel small-molecule inhibitor that targets multiple oncogenic pathways, including FLT3, CDK4/6, and Aurora kinases. Its multi-targeted action makes it effective against a range of cancers, particularly hematologic malignancies such as acute myeloid leukemia (AML) with FLT3 mutations. FN-1501 disrupts cell cycle progression, induces apoptosis, and inhibits tumor cell proliferation by simultaneously targeting these key regulators of cell division and survival. This broad-spectrum inhibition provides a promising therapeutic approach for cancers driven by dysregulated kinase activity, offering potential for use in combination therapies and precision oncology treatments.
| Catalog Number | I020238 |
| CAS Number | 1429515-59-2 |
| Molecular Formula | C₂₂H₂₅N₉O |
| Purity | ≥95% |
| IUPAC Name | N-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-4-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1H-pyrazole-5-carboxamide |
| InChI | InChI=1S/C22H25N9O/c1-30-8-10-31(11-9-30)13-15-2-4-16(5-3-15)27-22(32)19-18(12-26-29-19)28-21-17-6-7-23-20(17)24-14-25-21/h2-7,12,14H,8-11,13H2,1H3,(H,26,29)(H,27,32)(H2,23,24,25,28) |
| InChIKey | VXLAKHWYGRKCGI-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)CC2=CC=C(C=C2)NC(=O)C3=C(C=NN3)NC4=NC=NC5=C4C=CN5 |
| Reference | [1]. Wang Y, et al. Discovery of 4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide (FN-1501), an FLT3- and CDK-Kinase Inhibitor with Potentially High Efficiency against Acute Myelocytic Leukemia. J Med Chem. 2018 Feb 22;61(4):1499-1518. |
