Folate-PEG3-alkyne

• CAT Number: I015292
• CAS Number: 1245285-73-7
• Molecular Formula: C₂₈H₃₄N₈O₈
• Molecular Weight: 610.62
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: (2S)-2-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methylamino]benzoyl]amino]-5-oxo-5-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethylamino]pentanoic acid
• InChI: 1S/C28H34N8O8/c1-2-10-42-12-14-44-15-13-43-11-9-30-22(37)8-7-21(27(40)41)34-25(38)18-3-5-19(6-4-18)31-16-20-17-32-24-23(33-20)26(39)36-28(29)35-24/h1,3-6,17,21,31H,7-16H2,(H,30,37)(H,34,38)(H,40,41)(H3,29,32,35,36,39)/t21-/m0/s1
• InChIKey: BTQOUUGJBSCVDT-NRFANRHFSA-N
• SMILES: C#CCOCCOCCOCCNC(=O)CC[C@@H](C(=O)O)NC(=O)C1=CC=C(C=C1)NCC2=CN=C3C(=N2)C(=O)NC(=N3)N

Folate-PEG3-alkyne (Cat No.: I015292) is a multifunctional linker molecule combining a folate moiety, a PEG3 (triethylene glycol) spacer, and a terminal alkyne group. The folate enables targeted delivery to cells overexpressing folate receptors, commonly found in cancer cells. The PEG3 spacer enhances solubility and reduces steric hindrance, while the alkyne group allows for bioorthogonal click chemistry conjugation. This reagent is widely used in targeted drug delivery, imaging, and diagnostics, particularly in the development of antibody-drug conjugates and folate receptor-targeted therapeutics.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.