For research use only. Not for therapeutic Use.
Folic acid（Cat No.:I004223）, also known as Vitamin M or Vitamin B9, is an essential B vitamin that plays a crucial role in various cellular processes. It is necessary for the production and maintenance of new cells, including red blood cells, and is involved in DNA synthesis and RNA synthesis. Folic acid is particularly important during periods of rapid cell division and growth, such as during pregnancy and infancy. Adequate intake of folic acid is essential for overall health and is commonly supplemented to prevent deficiencies and support proper cell function.
| Catalog Number | I004223 |
| CAS Number | 59-30-3 |
| Synonyms | NSC 3073;Vitamin B9 |
| Molecular Formula | C19H19N7O6 |
| Purity | ≥95% |
| Target | Cell Cycle/DNA Damage |
| Solubility | 10 mM in H2O |
| Storage | 2-8°C |
| IUPAC Name | (2S)-2-[[4-[(2-amino-4-oxo-3H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid |
| InChI | InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1 |
| InChIKey | OVBPIULPVIDEAO-LBPRGKRZSA-N |
| SMILES | C1=CC(=CC=C1C(=O)NC(CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)NC(=N3)N |
| Reference | </br>1:Folic Acid Modulates DMBA/TPA-Induced Changes in Skin of Mice: A Study Relevant to Carcinogenesis. Koul A, Kaur N, Chugh NA.J Diet Suppl. 2017 May 17:16. doi: 10.1080/19390211.2017.1322659. [Epub ahead of print] PMID: 28514181 </br>2:Ethnic differences in folic acid supplement use in a population-based cohort of pregnant women in Norway. Kinnunen TI, Sletner L, Sommer C, Post MC, Jenum AK.BMC Pregnancy Childbirth. 2017 May 15;17(1):143. doi: 10.1186/s12884-017-1292-x. PMID: 28506268 Free PMC Article</br>3:A pH-sensitive delivery vehicle based on folic acid-conjugated polydopamine-modified mesoporous silica nanoparticles for targeted cancer therapy. Cheng W, Nie J, Xu L, Liang C, Peng Y, Liu G, Wang T, Mei L, Huang L, Zeng X.ACS Appl Mater Interfaces. 2017 May 12. doi: 10.1021/acsami.7b02457. [Epub ahead of print] PMID: 28497681 </br>4:An overview of folate status in a population-based study from São Paulo, Brazil and the potential impact of 10 years of national folic acid fortification policy. Steluti J, Selhub J, Paul L, Reginaldo C, Fisberg RM, Marchioni DML.Eur J Clin Nutr. 2017 May 10. doi: 10.1038/ejcn.2017.60. [Epub ahead of print] PMID: 28488686 </br>5:Biodegradable poly(D,L-lactide-co-glycolide)/poly(L-γ-glutamic acid) nanoparticles conjugated to folic acid for targeted delivery of doxorubicin. Jaimes-Aguirre L, Morales-Avila E, Ocampo-García BE, Medina LA, López-Téllez G, Gibbens-Bandala BV, Izquierdo-Sánchez V.Mater Sci Eng C Mater Biol Appl. 2017 Jul 1;76:743-751. doi: 10.1016/j.msec.2017.03.145. Epub 2017 Mar 18. PMID: 28482586 </br>6:Folic acid-tagged titanium dioxide nanoparticles for enhanced anticancer effect in osteosarcoma cells. Ai JW, Liu B, Liu WD.Mater Sci Eng C Mater Biol Appl. 2017 Jul 1;76:1181-1187. doi: 10.1016/j.msec.2017.03.027. Epub 2017 Mar 6. PMID: 28482484 </br>7:Vitamin B12, folic acid, homocysteine and vitamin D levels in children and adolescents with obsessive compulsive disorder. Esnafoğlu E, Yaman E.Psychiatry Res. 2017 Apr 21;254:232-237. doi: 10.1016/j.psychres.2017.04.032. [Epub ahead of print] PMID: 28477545 </br>8:Folic Acid Supplementation Delays Atherosclerotic Lesion Development by Modulating MCP1 and VEGF DNA Methylation Levels In Vivo and In Vitro. Cui S, Li W, Lv X, Wang P, Gao Y, Huang G.Int J Mol Sci. 2017 May 5;18(5). pii: E990. doi: 10.3390/ijms18050990. PMID: 28475147 Free Article</br>9:Folic Acid is Necessary for Proliferation and Differentiation of C2C12 Myoblasts. Hwang SY, Kang YJ, Sung B, Jang JY, Hwang NL, Oh HJ, Ahn YR, Kim HJ, Shin J, Yoo MA, Kim CM, Chung HY, Kim ND.J Cell Physiol. 2017 May 4. doi: 10.1002/jcp.25989. [Epub ahead of print] PMID: 28471487 </br>10:Melatonin promoted renal regeneration in folic acid-induced acute kidney injury via inhibiting nucleocytoplasmic translocation of HMGB1 in tubular epithelial cells. Zhu F, Chong Lee Shin OL, Xu H, Zhao Z, Pei G, Hu Z, Yang J, Guo Y, Mou J, Sun J, Zhu H, Wang Y, Wang M, Yang Q, Liao W, Xu G, Zeng R, Yao Y.Am J Transl Res. 2017 Apr 15;9(4):1694-1707. eCollection 2017. PMID: 28469775 Free PMC Article |
