Fomepizole

• CAT Number: A000752
• CAS Number: 7554-65-6
• Molecular Formula: C4H6N2
• Molecular Weight: 82.106
• Purity: ≥95%
• Synonyms: 4-Methylpyrazole; 4-Methyl-1H-pyrazole; Fomepizole; 7554-65-6; Antizol; 1H-Pyrazole, 4-methyl-
• Target: Cytochrome P450
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: 4-methyl-1H-pyrazole
• InChI: InChI=1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)
• InChIKey: RIKMMFOAQPJVMX-UHFFFAOYSA-N
• SMILES: CC1=CNN=C1

Fomepizole, also known as 4-Methylpyrazole and Antizol, is an alcohol dehydrogenase inhibitor used for the treatment of ethylene glycol and methanol poisonings in adults. Fomepizole is a competitive antagonist of alcohol dehydrogenase with a binding affinity >8000 times that of ethanol.

Reference

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9: Darracq MA, Rentmeester LL, Clark RF, Tomaszewski CA, Schneir AB, Cantrell FL.
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