For research use only. Not for therapeutic Use.
Formycin A (Cat No.:I017268) is a purine nucleoside antibiotic and a potent inhibitor of human immunodeficiency virus type 1 (HIV-1), with an EC50 of 10 μM. It exhibits antitumor and antiviral activities, making it a promising drug candidate for the treatment of HIV-1 and cancer. Formycin A works by interfering with the synthesis of viral DNA and RNA, preventing the replication of HIV-1 and inhibiting tumor cell growth.
| Catalog Number | I017268 |
| CAS Number | 6742-12-7 |
| Molecular Formula | C₁₀H₁₃N₅O₄ |
| Purity | ≥95% |
| Storage | −20°C |
| IUPAC Name | (2S,3R,4S,5R)-2-(7-amino-2H-pyrazolo[4,3-d]pyrimidin-3-yl)-5-(hydroxymethyl)oxolane-3,4-diol |
| InChI | InChI=1S/C10H13N5O4/c11-10-6-4(12-2-13-10)5(14-15-6)9-8(18)7(17)3(1-16)19-9/h2-3,7-9,16-18H,1H2,(H,14,15)(H2,11,12,13)/t3-,7-,8-,9+/m1/s1 |
| InChIKey | KBHMEHLJSZMEMI-KSYZLYKTSA-N |
| SMILES | C1=NC2=C(NN=C2C(=N1)N)C3C(C(C(O3)CO)O)O |
| Reference | [1]. Dapp MJ , et al. Discovery of novel ribonucleoside analogs with activity against human immunodeficiency virus type 1.J Virol. 2014 Jan;88(1):354-63.<br>[2]. Zhang M, et al. Comparative Investigation into Formycin A and Pyrazofurin A Biosynthesis Reveals Branch Pathways for the Construction of C-Nucleoside Scaffolds. Appl Environ Microbiol. 2020 Jan 7;86(2). |
