Formycin B

• CAT Number: M058130
• CAS Number: 13877-76-4
• Molecular Formula: C10H12N4O5
• Molecular Weight: 268.229
• Purity: 97%
• Synonyms: Laurusin; Ohyamycin; 1,4-DIHYDRO-3-BETA-D-RIBOFURANOSYL-7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE
• Storage: Store at -20°C
• IUPAC Name: 3-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4-dihydropyrazolo[4,3-d]pyrimidin-7-one
• InChI: InChI=1S/C10H12N4O5/c15-1-3-7(16)8(17)9(19-3)5-4-6(14-13-5)10(18)12-2-11-4/h2-3,7-9,15-17H,1H2,(H,13,14)(H,11,12,18)/t3-,7-,8-,9+/m1/s1
• InChIKey: MTCJZZBQNCXKAP-KSYZLYKTSA-N
• SMILES: C1=NC(=O)C2=NNC(=C2N1)C3C(C(C(O3)CO)O)O

Formycin B (Cat.No:M058130) is a naturally occurring nucleoside antibiotic derived from Streptomyces cultures. It possesses antiviral properties due to its inhibition of nucleic acid synthesis. Formycin B’s unique structure, resembling nucleosides, contributes to its potential in antiviral and antitumor research, making it valuable in medicinal chemistry investigations.

Reference

1.Wu, Xiaochun, Andrew C. Hui, and Kathleen M. Giacomini. "Formycin B elimination from the cerebrospinal fluid of the rat." Pharmaceutical research 10.4 (1993): 611-615.
2.Burke, Trisha, et al. "Interaction of 2′, 2′-difluorodeoxycytidine (gemcitabine) and formycin B with the Na+-dependent and-independent nucleoside transporters of Ehrlich ascites tumor cells." Journal of Pharmacology and Experimental Therapeutics 286.3 (1998): 1333-1340.