Fortunellin

• CAT Number: I027707
• CAS Number: 20633-93-6
• Molecular Formula: C28H32O14
• Molecular Weight: 592.55
• Purity: 98%
• Synonyms: Fortunellin
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 4H-1-Benzopyran-4-one, 7-((2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)-oxy)-5-hydroxy-2-(4-methoxyphenyl)-
• InChI: InChI=1S/C28H32O14/c1-11-21(32)23(34)25(36)27(38-11)42-26-24(35)22(33)19(10-29)41-28(26)39-14-7-15(30)20-16(31)9-17(40-18(20)8-14)12-3-5-13(37-2)6-4-12/h3-9,11,19,21-30,32-36H,10H2,1-2H3/t11-,19+,21-,22+,23+,24-,25+,26+,27-,28+/m0/s1
• InChIKey: MLWDGPFGTFOLRJ-CUVHLRMHSA-N
• SMILES: O=C1C=C(C2=CC=C(OC)C=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O[C@H]5[C@@H]([C@@H]([C@H]([C@H](C)O5)O)O)O)=CC(O)=C13

Fortunellin is an antioxidant and anti-inflammatory agent that has been active against inflammation and oxidative stress that contribute to the progression of diabetic cardiomyopathy (DCM). Fortunellin may alleviate heart function and reduce inflammation and oxidative stress. The pro-inflammatory cytokines and the expression of p-IκB kinase α (IKKα), p-IκBα, and p-nuclear factor-κB (NF-κB) are inhibited by Fortunellin, while superoxide dismutase (SOD), catalase (CAT), heme oxygenase-1 (HO-1) and p-AMP-activated protein kinase (AMPK) were significantly enhanced. Fortunellin likely protects against fructose-induced inflammation and oxidative stress by enhancing AMPK/Nrf2 pathway in diabetic mice and cardiomyocytes with fructose treatment.

Reference

1: Zhao C, Zhang Y, Liu H, Li P, Zhang H, Cheng G. Fortunellin protects against high fructose-induced diabetic heart injury in mice by suppressing inflammation and oxidative stress via AMPK/Nrf-2 pathway regulation. Biochem Biophys Res Commun. 2017 Aug 19;490(2):552-559. doi: 10.1016/j.bbrc.2017.06.076. Epub 2017 Jun 15. PubMed PMID: 28624452.
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5: Ge YB. [Chemical constituents of Fortunella margarita fruits]. Zhong Yao Cai. 2014 Mar;37(3):435-8. Chinese. PubMed PMID: 25174109.