For research use only. Not for therapeutic Use.
Fosamprenavir Calcium Salt（Cat No.:I002734）is a high-purity prodrug of amprenavir, widely used in antiviral research targeting HIV-1. It undergoes enzymatic conversion to release active amprenavir, a potent HIV-1 protease inhibitor that blocks viral replication by preventing protease-mediated cleavage of viral polyproteins. The calcium salt form enhances stability and solubility, making it ideal for pharmaceutical and virology studies. Fosamprenavir Calcium Salt is an essential tool for exploring HIV treatment strategies, drug resistance mechanisms, and the development of advanced antiretroviral therapies to combat HIV/AIDS.
| Catalog Number | I002734 |
| CAS Number | 226700-81-8 |
| Synonyms | calcium;[(2R,3S)-1-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-[[(3S)-oxolan-3-yl]oxycarbonylamino]-4-phenylbutan-2-yl] phosphate |
| Molecular Formula | C25H34N3O9PS • Ca |
| Purity | ≥95% |
| Target | Metabolic Enzyme/Protease |
| Solubility | 10 mM in H2O |
| Storage | Store at -20°C |
| IUPAC Name | calcium;[(2R,3S)-1-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-[[(3S)-oxolan-3-yl]oxycarbonylamino]-4-phenylbutan-2-yl] phosphate |
| InChI | InChI=1S/C25H36N3O9PS.Ca/c1-18(2)15-28(39(33,34)22-10-8-20(26)9-11-22)16-24(37-38(30,31)32)23(14-19-6-4-3-5-7-19)27-25(29)36-21-12-13-35-17-21;/h3-11,18,21,23-24H,12-17,26H2,1-2H3,(H,27,29)(H2,30,31,32);/q;+2/p-2/t21-,23-,24+;/m0./s1 |
| InChIKey | PMDQGYMGQKTCSX-HQROKSDRSA-L |
| SMILES | CC(C)CN(C[C@H]([C@H](CC1=CC=CC=C1)NC(=O)O[C@H]2CCOC2)OP(=O)([O-])[O-])S(=O)(=O)C3=CC=C(C=C3)N.[Ca+2] |
| Reference | <p style=/line-height:25px/> <br>[2]. Cao YJ, Smith PF, Wire MB, Pharmacokinetics and pharmacodynamics of methadone enantiomers after coadministration with fosamprenavir-ritonavir in opioid-dependent subjects. Pharmacotherapy. 2008 Jul;28(7):863-74. <br>[3]. Falcoz C, Jenkins JM, Bye C, Pharmacokinetics of GW433908, a prodrug of amprenavir, in healthy male volunteers. J Clin Pharmacol. 2002 Aug;42(8):887-98. </p> |
