Fosaprepitant Dibenzyl Ester

• CAT Number: C000209
• CAS Number: 265121-01-5
• Molecular Formula: C₃₇H₃₄F₇N₄O₆P
• Molecular Weight: 794.65
• Purity: ≥95%
• Synonyms: [3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(Trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]-phosphonic Acid bis(Phenylmethyl) Ester; Dibenzyl Fosaprepitant
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Appearance: White to Light Yellow Solid
• Storage: -20°C, Hygroscopic

Fosaprepitant Dibenzyl Ester(CAT: C000209) is a significant compound in the realm of medicinal chemistry and drug development. It plays a crucial role as a reactant in the synthesis of phosphorylated morpholine acetal human neurokinin-1 receptor antagonists. These compounds are designed as water-soluble prodrugs, which means they can be converted into their active form within the body.

Reference

Hale, J., et al.: J. Med. Chem., 43, 1234 (2000);