Fosbretabulin tromethamine

• CAT Number: I027711
• CAS Number: 404886-32-4
• Molecular Formula: C22H32NO11P
• Molecular Weight: 517.47
• Purity: 98%
• Synonyms: Fosbretabulin tromethamine; Zybrestat
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2-amino-2-(hydroxymethyl)propane-1,3-diol (Z)-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl phosphate
• InChI: InChI=1S/C18H21O8P.C4H11NO3/c1-22-14-8-7-12(9-15(14)26-27(19,20)21)5-6-13-10-16(23-2)18(25-4)17(11-13)24-3;5-4(1-6,2-7)3-8/h5-11H,1-4H3,(H2,19,20,21);6-8H,1-3,5H2/b6-5-
• InChIKey: FIDMEHCRMLKKPZ-YSMBQZINSA-N
• SMILES: COc1ccc(C=C/c2cc(OC)c(OC)c(OC)c2)cc1OP(=O)(O)O.NC(CO)(CO)CO

Fosbretabulin Tromethamine(CAT: I027711) is a vascular-disrupting agent (VDA) with significant applications in oncology research. It targets the tubulin cytoskeleton of endothelial cells in tumor vasculature, disrupting microtubule dynamics and leading to rapid vascular collapse and tumor necrosis. This selective mechanism spares normal tissues, making it a critical tool for studying tumor angiogenesis and hypoxia. Fosbretabulin Tromethamine is particularly useful in exploring combination therapies with anti-angiogenic agents and radiation, as well as investigating resistance mechanisms. Its ability to induce tumor ischemia highlights its potential in developing innovative cancer treatments.