Fosfomycin Disodium Salt

• CAT Number: R007128
• CAS Number: 26016-99-9
• Molecular Formula: C3H5Na2O4P
• Molecular Weight: 182.02
• Purity: ≥95%
• Synonyms: Phosphomycin Disodium Salt; Disodium (1R,2S)-(1,2-epoxypropyl)phosphonate
• Target: Bacterial
• Storage: -20°C
• IUPAC Name: disodium;[(2R,3S)-3-methyloxiran-2-yl]-dioxido-oxo-lambda5-phosphane
• InChI: InChI=1S/C3H7O4P.2Na/c1-2-3(7-2)8(4,5)6;;/h2-3H,1H3,(H2,4,5,6);;/q;2*+1/p-2/t2-,3+;;/m0../s1
• InChIKey: QZIQJIKUVJMTDG-JSTPYPERSA-L
• SMILES: C[C@H]1[C@H](O1)P(=O)([O-])[O-].[Na+].[Na+]

Fosfomycin Disodium Salt（Cat No.:R007128）is a broad-spectrum antibiotic effective against both Gram-positive and Gram-negative bacteria, particularly Escherichia coli and other pathogens causing urinary tract infections (UTIs). It works by inhibiting the bacterial enzyme enolpyruvyl transferase, a critical enzyme in cell wall synthesis, leading to bacterial cell death. Fosfomycin’s unique mechanism and low resistance profile make it valuable for treating multidrug-resistant infections. The disodium salt form enhances its solubility and stability, making it suitable for intravenous administration in clinical settings, particularly in severe or complicated infections.

Reference

Falagas, Matthew E., and Antonia C. Kastaris. /Fosfomycin for the Treatment of Multidrug-resistant, including Extended-spectrum β-lactamase Producing, Enterobacteriaceae Infections: A Systematic Review./ The Lancet: Infectious Diseases 10 (2010): 43-50. Antimicrobe.org. Web. 21 Aug. 2012.