For research use only. Not for therapeutic Use.
Fosmidomycin Sodium（Cat No.:I006850）is a potent antibiotic and antimalarial agent that targets the non-mevalonate pathway of isoprenoid biosynthesis by inhibiting the enzyme 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR). Originally derived from Streptomyces lavendulae, it is particularly effective against Plasmodium falciparum, the parasite responsible for malaria, making it valuable in antimalarial research. Fosmidomycin Sodium also shows antibacterial activity against certain Gram-negative bacteria, broadening its application in infectious disease studies. Its unique mechanism of action, distinct from traditional antibiotics, highlights its potential as a novel therapeutic option in combating resistant pathogens and malaria.
| Catalog Number | I006850 |
| CAS Number | 66508-37-0 (sodium) |
| Synonyms | Fosmidomycin sodium; FR-31564; FR 31564; FR31564.;(3-(Formylhydroxyamino)propyl)phosphonic acid monosodium salt |
| Molecular Formula | C4H9NNaO5P |
| Purity | ≥95% |
| Target | Bacterial |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term or -20 °C for long term |
| IUPAC Name | sodium;3-[formyl(hydroxy)amino]propyl-hydroxyphosphinate |
| InChI | InChI=1S/C4H10NO5P.Na/c6-4-5(7)2-1-3-11(8,9)10;/h4,7H,1-3H2,(H2,8,9,10);/q;+1/p-1 |
| InChIKey | ZZPUYRHMTGOTEU-UHFFFAOYSA-M |
| SMILES | C(CN(C=O)O)CP(=O)(O)[O-].[Na+] |
| Reference | </br> 1:Sooriyaarachchi S, Chofor R, Risseeuw MD, Bergfors T, Pouyez J, Dowd CS, Maes L, Wouters J, Jones TA, Van Calenbergh S, Mowbray SL. Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with β-Arylpropyl Analogues of Fosmidomycin. ChemMedChem. 2016 Sep 20;11(18):2024-36. doi: 10.1002/cmdc.201600249. Epub 2016 Aug 3. PubMed PMID: 27487410. |
