For research use only. Not for therapeutic Use.
Fosnetupitant chloride monohydrochloride（Cat No.:I027727）is a prodrug of netupitant, a selective neurokinin-1 (NK1) receptor antagonist. It is used in the prevention of chemotherapy-induced nausea and vomiting (CINV), particularly in patients undergoing highly emetogenic chemotherapy. By inhibiting the NK1 receptor, which is involved in the signaling of substance P, a neuropeptide that triggers vomiting, fosnetupitant helps reduce the severity and frequency of nausea and vomiting. This compound is typically used in combination with other antiemetic agents and is being studied for its effectiveness and safety in managing CINV and other related conditions.
| CAS Number | 1643757-72-5 |
| Synonyms | [4-[5-[[2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl]-methylamino]-4-(2-methylphenyl)pyridin-2-yl]-1-methylpiperazin-1-ium-1-yl]methyl dihydrogen phosphate;chloride;hydrochloride |
| Molecular Formula | C31H37Cl2F6N4O5P |
| Purity | ≥95% |
| IUPAC Name | [4-[5-[[2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl]-methylamino]-4-(2-methylphenyl)pyridin-2-yl]-1-methylpiperazin-1-ium-1-yl]methyl dihydrogen phosphate;chloride;hydrochloride |
| InChI | InChI=1S/C31H35F6N4O5P.2ClH/c1-20-8-6-7-9-24(20)25-17-27(40-10-12-41(5,13-11-40)19-46-47(43,44)45)38-18-26(25)39(4)28(42)29(2,3)21-14-22(30(32,33)34)16-23(15-21)31(35,36)37;;/h6-9,14-18H,10-13,19H2,1-5H3,(H-,43,44,45);2*1H |
| InChIKey | LBTQUZNIWCWBNN-UHFFFAOYSA-N |
| SMILES | CC1=CC=CC=C1C2=CC(=NC=C2N(C)C(=O)C(C)(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4CC[N+](CC4)(C)COP(=O)(O)O.Cl.[Cl-] |
