Fosnetupitant

• CAT Number: I048026
• CAS Number: 1703748-89-3
• Molecular Formula: C31H35F6N4O5P
• Molecular Weight: 688.6
• Purity: ≥95%
• Synonyms: Fosnetupitant [INN]; 07-PNET; UNII-T672P80L2S
• Target: HTR3A TACR1
• Target Protein: HZIYEEMJNBKMJH-UHFFFAOYSA-N
• Appearance: Solid
• IC50: pKi: 9.5(human NK1 receptor)
• IUPAC Name: [4-[5-[[2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoyl]-methylamino]-4-(2-methylphenyl)pyridin-2-yl]-1-methylpiperazin-1-ium-1-yl]methyl hydrogen phosphate
• InChI: InChI=1S/C31H35F6N4O5P/c1-20-8-6-7-9-24(20)25-17-27(40-10-12-41(5,13-11-40)19-46-47(43,44)45)38-18-26(25)39(4)28(42)29(2,3)21-14-22(30(32,33)34)16-23(15-21)31(35,36)37/h6-9,14-18H,10-13,19H2,1-5H3,(H-,43,44,45)
• SMILES: CC1=CC=CC=C1C2=CC(=NC=C2N(C)C(=O)C(C)(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4CC[N+](CC4)(C)COP(=O)(O)[O-]

Fosnetupitant is a medication used in combination with palonosetron to prevent nausea and vomiting caused by chemotherapy. It belongs to a class of drugs known as neurokinin-1 (NK-1) receptor antagonists, which work by blocking the action of substance P, a neurotransmitter involved in nausea and vomiting. By inhibiting the NK-1 receptor, fosnetupitant helps to prevent chemotherapy-induced nausea and vomiting (CINV). Fosnetupitant is typically administered intravenously before chemotherapy and has been shown to be effective in clinical trials for both acute and delayed CINV. It is considered a valuable option for improving the quality of life for cancer patients undergoing chemotherapy.