For research use only. Not for therapeutic Use.
Fostemsavir（Cat No.:I006855）is an antiretroviral prodrug used in the treatment of HIV-1 infection in heavily treatment-experienced patients. Once metabolized into its active form, temsavir, it acts as an attachment inhibitor, blocking the interaction between the HIV-1 envelope glycoprotein (gp120) and the CD4 receptor on host cells. This prevents the virus from entering and infecting cells. Fostemsavir is particularly effective in patients with multidrug-resistant HIV strains, offering a new treatment option where other therapies have failed. Its unique mechanism provides critical support in managing resistant HIV infections.
| Catalog Number | I006855 |
| CAS Number | 864953-29-7 |
| Synonyms | [3-[2-(4-benzoylpiperazin-1-yl)-2-oxoacetyl]-4-methoxy-7-(3-methyl-1,2,4-triazol-1-yl)pyrrolo[2,3-c]pyridin-1-yl]methyl dihydrogen phosphate |
| Molecular Formula | C25H26N7O8P |
| Purity | 98% |
| Target | HIV gp120 |
| Target Protein | |
| Appearance | Solid |
| Storage | Dry, dark and at 2 - 8 °C for six months or -20°C for two years. |
| IC50 | IC50:<100 nM |
| IUPAC Name | [3-[2-(4-benzoylpiperazin-1-yl)-2-oxoacetyl]-4-methoxy-7-(3-methyl-1,2,4-triazol-1-yl)pyrrolo[2,3-c]pyridin-1-yl]methyl dihydrogen phosphate |
| InChI | InChI=1S/C25H26N7O8P/c1-16-27-14-32(28-16)23-21-20(19(39-2)12-26-23)18(13-31(21)15-40-41(36,37)38)22(33)25(35)30-10-8-29(9-11-30)24(34)17-6-4-3-5-7-17/h3-7,12-14H,8-11,15H2,1-2H3,(H2,36,37,38) |
| InChIKey | SWMDAPWAQQTBOG-UHFFFAOYSA-N |
| SMILES | CC1=NN(C=N1)C2=NC=C(C3=C2N(C=C3C(=O)C(=O)N4CCN(CC4)C(=O)C5=CC=CC=C5)COP(=O)(O)O)OC |
| Reference | [1]. Nowicka-Sans B, et al. In vitro antiviral characteristics of HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068. Antimicrob Agents Chemother. 2012 Jul;56(7):3498-507. |
