Fotagliptin benzoate

• CAT Number: I042028
• CAS Number: 1403496-40-1
• Molecular Formula: C24H25FN6O3
• Molecular Weight: 464.49
• Purity: ≥95%
• Synonyms: 2-[[3-[(3R)-3-aminopiperidin-1-yl]-6-methyl-5-oxo-1,2,4-triazin-4-yl]methyl]-4-fluorobenzonitrile;benzoic acid
• InChI: InChI=1S/C17H19FN6O.C7H6O2/c1-11-16(25)24(9-13-7-14(18)5-4-12(13)8-19)17(22-21-11)23-6-2-3-15(20)10-23;8-7(9)6-4-2-1-3-5-6/h4-5,7,15H,2-3,6,9-10,20H2,1H3;1-5H,(H,8,9)/t15-;/m1./s1
• InChIKey: CEIKPTLXEHWGMB-XFULWGLBSA-N
• SMILES: CC1=NN=C(N(C1=O)CC2=C(C=CC(=C2)F)C#N)N3CCCC(C3)N.C1=CC=C(C=C1)C(=O)O

Fotagliptin benzoate is a Dipeptidyl Peptidase IV (DPP-4) inhibitor (IC50=2.27 nM). Fotagliptin benzoate displays great security in rat and dog. Fotagliptin benzoate can be used for Type 2 diabetes mellitus research[1].
Fotagliptin benzoate (33 mg/kg or 110 mg/kg) is safe for rat and dog at different doses respectively[1].

Reference

[1]. Wang Z, et al. Development and validation of a UPLC-MS/MS method for simultaneous determination of fotagliptin and its two major metabolites in human plasma and urine. Bioanalysis. 2017 Feb;9(4):381-393.
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