FPI-1523 sodium

• CAT Number: I040698
• CAS Number: 1452459-52-7
• Molecular Formula: C9H13N4NaO7S
• Molecular Weight: 344.28
• Purity: ≥95%
• Synonyms: sodium;[(2S,5R)-2-(acetamidocarbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] sulfate
• InChI: InChI=1S/C9H14N4O7S.Na/c1-5(14)10-11-8(15)7-3-2-6-4-12(7)9(16)13(6)20-21(17,18)19;/h6-7H,2-4H2,1H3,(H,10,14)(H,11,15)(H,17,18,19);/q;+1/p-1/t6-,7+;/m1./s1
• InChIKey: ACQISEUSOMBVGU-HHQFNNIRSA-M
• SMILES: CC(=O)NNC(=O)C1CCC2CN1C(=O)N2OS(=O)(=O)[O-].[Na+]

FPI-1523 sodium, a derivative of Avibactam, is a potent β-lactamase inhibitor, with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 sodium also inhibits PBP2, with an IC50 of 3.2 μM. FPI-1523 sodium exhibits considerable antimicrobial activity[1].
FPI-1523 sodium inhibits K12 E. coli K12 and PBP2, with MIC and IC50 of 4 μg/mL and 0.4 μg/mL, respectively[1].
FPI-1523 sodium inhibit E. coli BW25113 pGDP-2 transformants either with an empty vector or expressing different β-lactamases, with low MICs (1-2 μM)[1].

Reference

[1]. King AM, et, al. Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-β-Lactamases and Penicillin-Binding Proteins. ACS Chem Biol. 2016 Apr 15;11(4):864-8.
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