FPL 62064

• CAT Number: I017261
• CAS Number: 103141-09-9
• Molecular Formula: C₁₆H₁₅N₃O
• Molecular Weight: 265.31
• Purity: ≥95%
• Target: Immunology/Inflammation
• Storage: Room Temperature
• IUPAC Name: N-(4-methoxyphenyl)-1-phenylpyrazol-3-amine
• InChI: InChI=1S/C16H15N3O/c1-20-15-9-7-13(8-10-15)17-16-11-12-19(18-16)14-5-3-2-4-6-14/h2-12H,1H3,(H,17,18)
• InChIKey: WKLGNFJHVJIZPK-UHFFFAOYSA-N
• SMILES: COC1=CC=C(C=C1)NC2=NN(C=C2)C3=CC=CC=C3

FPL 62064（Cat No.:I017261） is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and cyclooxygenase (COX), two enzymes involved in inflammatory processes. It has demonstrated significant anti-inflammatory activity by inhibiting the production of both leukotrienes (mediated by 5-LOX) and prostaglandins (mediated by COX). With IC50 values of 3.5 μM and 3.1 μM for inhibiting 5-LOX and COX, respectively, FPL 62064 holds promise as a therapeutic agent for conditions characterized by excessive inflammation.

Reference

[1]. Blackham A, et al. FPL 62064, a topically active 5-lipoxygenase/cyclooxygenase inhibitor. Agents Actions. 1990 Jun;30(3-4):432-42.[2]. Shabaan MA, et al. Synthesis and biological evaluation of pyrazolone analogues as potential anti-inflammatory agents targeting cyclooxygenases and 5-lipoxygenase. Arch Pharm (Weinheim). 2020 Feb 7:e1900308.