For research use only. Not for therapeutic Use.
FPR-A14 is a potent formyl peptide receptor (FPR) agonist. FPR-A14 is a potent activator of neutrophil Ca2+ mobilization and chemotaxis with EC50s of 630 nM and 42 nM, respectively. FPR-A14 induces cell differentiation[1][2].
FPR-A14 (compound 14) activates Ca2+ release with an EC50 of 630 nM in human neutrophils. FPR-A14 is a neutrophil chemoattractant and dose-dependently induces neutrophil migration with an EC50 value of 42 nM[1].
FPR-A14 (1-10 μM; 48h) elicites a significant increase in % cell differentiation versus controls at concentrations of 4μM (32.0%), 6μM (64.9%), 8μM (89.1%) and 10μM (93.3%) in mouse neuroblastoma N2a cells. FPRa14 (100μM) produces similar effects in IMR-32 and SH-SY5Y cells[2].
| Catalog Number | I010638 |
| CAS Number | 329691-12-5 |
| Synonyms | N-[(E)-(3-methoxy-4-phenylmethoxyphenyl)methylideneamino]-1,3-benzodioxole-5-carboxamide |
| Molecular Formula | C23H20N2O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C23H20N2O5/c1-27-21-11-17(7-9-19(21)28-14-16-5-3-2-4-6-16)13-24-25-23(26)18-8-10-20-22(12-18)30-15-29-20/h2-13H,14-15H2,1H3,(H,25,26)/b24-13+ |
| InChIKey | ULOKADSYVZOTTL-ZMOGYAJESA-N |
| SMILES | COC1=C(C=CC(=C1)C=NNC(=O)C2=CC3=C(C=C2)OCO3)OCC4=CC=CC=C4 |
| Reference | [1]. Igor A Schepetkin, et al. High-throughput screening for small-molecule activators of neutrophils: identification of novel N-formyl peptide receptor agonists. Mol Pharmacol. 2007 Apr;71(4):1061-74. [2]. Peter J G Cussell, et al. The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically. inhibited with FPR antagonists and FPR knockdown using siRNA. PLoS One. 2019 Jun 6;14(6):e0217815. |
