FPS-ZM1

• CAT Number: I005629
• CAS Number: 945714-67-0
• Molecular Formula: C₂₀H₂₂ClNO
• Molecular Weight: 327.85
• Purity: ≥95%
• Synonyms: 4-chloro-N-cyclohexyl-N-(phenylmethyl)-benzamide
• Target: Amyloid-β
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 25 ± 5 nM (Ki)
• IUPAC Name: N-benzyl-4-chloro-N-cyclohexylbenzamide
• InChI: InChI=1S/C20H22ClNO/c21-18-13-11-17(12-14-18)20(23)22(19-9-5-2-6-10-19)15-16-7-3-1-4-8-16/h1,3-4,7-8,11-14,19H,2,5-6,9-10,15H2
• InChIKey: XDFKWGIBQMHSOH-UHFFFAOYSA-N
• SMILES: C1CCC(CC1)N(CC2=CC=CC=C2)C(=O)C3=CC=C(C=C3)Cl

FPS-ZM1(CAT: I005629) is a high-affinity, RAGE-specific inhibitor widely utilized in neurodegenerative and inflammatory disease research. By blocking amyloid-beta (Aβ) binding to the V domain of the receptor for advanced glycation end products (RAGE) with a Ki of 25 ± 5 nM in RAGE-transfected CHO cells, it effectively disrupts RAGE-mediated signaling pathways. This mechanism makes FPS-ZM1 a valuable tool for exploring the pathogenesis of Alzheimer’s disease, diabetic complications, and other RAGE-associated conditions. Its high specificity and potency ensure reliable results in in vitro and in vivo studies, advancing the development of therapeutic strategies targeting RAGE.