For research use only. Not for therapeutic Use.
FR-122047 HCl（Cat No.:I006609）is a hydrochloride salt form of FR-122047, a selective and potent inhibitor of the protein receptor 5-HT1A, a subtype of serotonin receptors. It has shown promise in preclinical studies for its potential use in treating anxiety, depression, and other central nervous system (CNS) disorders. By modulating serotonin signaling, FR-122047 HCl may help balance neurotransmitter activity, offering therapeutic effects in mood regulation and stress response. Its pharmacological properties are still under investigation, with ongoing research to determine its safety and efficacy in clinical settings.
| Catalog Number | I006609 |
| CAS Number | 130717-51-0 |
| Synonyms | FR-122047; FR 122047; FR122047.;(4,5-bis(4-methoxyphenyl)thiazol-2-yl)(4-methylpiperazin-1-yl)methanone hydrochloride |
| Molecular Formula | C23H26ClN3O3S |
| Purity | ≥95% |
| Target | COX |
| Solubility | Soluble in DMSO, not in water |
| Storage | Store at 4°C |
| IC50 | 0.028μM |
| IUPAC Name | [4,5-bis(4-methoxyphenyl)-1,3-thiazol-2-yl]-(4-methylpiperazin-1-yl)methanone;hydrochloride |
| InChI | InChI=1S/C23H25N3O3S.ClH/c1-25-12-14-26(15-13-25)23(27)22-24-20(16-4-8-18(28-2)9-5-16)21(30-22)17-6-10-19(29-3)11-7-17;/h4-11H,12-15H2,1-3H3;1H |
| InChIKey | YWMAVHIKOAOSFM-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)C(=O)C2=NC(=C(S2)C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC.Cl |
| Reference | </br> 1:Sandberg M, Jansson L. Effects of cyclooxygenase inhibition on insulin release and pancreatic islet blood flow in rats. Ups J Med Sci. 2014 Nov;119(4):316-23. doi: 10.3109/03009734.2014.964381. Epub 2014 Oct 7. PubMed PMID: 25291145; PubMed Central PMCID: PMC4248071. |
