FR-193262

• CAT Number: I006877
• CAS Number: 187992-22-9(FR-193262); 314289-63-9 (FR-193262 Free Base)
• Molecular Formula: C31H29N2NaO4
• Molecular Weight: 516.56
• Purity: ≥95%
• Synonyms: FR-193262; FR 193262; FR193262; FR-193262 Free Base.;Acetic acid, (((5R)-5-((2R)-2-(4,5-diphenyl-2-oxazolyl)-1-pyrrolidinyl)-5,6,7,8-tetrahydro-1-naphthalenyl)oxy)-, sodium salt
• Solubility: Soluble in DMSO
• Storage: 0 - 4°C for short term or -20 °C for long term
• IUPAC Name: sodium;2-[[(5R)-5-[(2R)-2-(4,5-diphenyl-1,3-oxazol-2-yl)pyrrolidin-1-yl]-5,6,7,8-tetrahydronaphthalen-1-yl]oxy]acetate
• InChI: InChI=1S/C31H30N2O4.Na/c34-28(35)20-36-27-18-8-14-23-24(27)15-7-16-25(23)33-19-9-17-26(33)31-32-29(21-10-3-1-4-11-21)30(37-31)22-12-5-2-6-13-22;/h1-6,8,10-14,18,25-26H,7,9,15-17,19-20H2,(H,34,35);/q;+1/p-1/t25-,26-;/m1./s1
• InChIKey: NRXVVCOCESTRSY-JUJAXGASSA-M
• SMILES: C1C[C@H](C2=C(C1)C(=CC=C2)OCC(=O)[O-])N3CCC[C@@H]3C4=NC(=C(O4)C5=CC=CC=C5)C6=CC=CC=C6.[Na+]

FR-193262(CACT: I006877) is a potent, selective inhibitor of fibroblast growth factor receptor (FGFR) tyrosine kinases, playing a critical role in regulating cell proliferation, differentiation, and angiogenesis. By targeting FGFR-mediated signaling pathways, it inhibits aberrant growth and survival signals in cancer cells, particularly in malignancies driven by FGFR mutations or amplifications. This compound is widely utilized in oncology research to study tumor progression, therapeutic resistance, and targeted treatment strategies. FR-193262 is a valuable tool for exploring the therapeutic potential of FGFR inhibition in cancer and related diseases.