For research use only. Not for therapeutic Use.
FR-217840 is a novel matrix metalloproteinase inhibitor. FR-217840 successfully suppresses joint destruction and suggest that FR217840 may have potential as a novel anti-rheumatic drug.
| Catalog Number | I006882 |
| CAS Number | 848444-16-6 |
| Synonyms | FR-217840; FR217840; FR 217840.;2-Piperazinecarboxamide, 1-((5-(4-fluorophenyl)-2-thienyl)sulfonyl)-N-hydroxy-4-(methylsulfonyl)-, (2S)- |
| Molecular Formula | C16H18FN3O6S3 |
| Purity | ≥95% |
| Target | metalloproteinase inhibitor |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term or -20 °C for long term |
| IUPAC Name | (2S)-1-[5-(4-fluorophenyl)thiophen-2-yl]sulfonyl-N-hydroxy-4-methylsulfonylpiperazine-2-carboxamide |
| InChI | InChI=1S/C16H18FN3O6S3/c1-28(23,24)19-8-9-20(13(10-19)16(21)18-22)29(25,26)15-7-6-14(27-15)11-2-4-12(17)5-3-11/h2-7,13,22H,8-10H2,1H3,(H,18,21)/t13-/m0/s1 |
| InChIKey | YFWUVSPVKPCLSA-ZDUSSCGKSA-N |
| SMILES | CS(=O)(=O)N1CCN(C(C1)C(=O)NO)S(=O)(=O)C2=CC=C(S2)C3=CC=C(C=C3)F |
| Reference | </br>1:Ishikawa T, Nishigaki F, Miyata S, Hirayama Y, Minoura K, Imanishi J, Neya M, Mizutani T, Imamura Y, Ohkubo Y, Mutoh S. Prevention of progressive joint destruction in adjuvant induced arthritis in rats by a novel matrix metalloproteinase inhibitor, FR217840. Eur J Pharmacol. 2005 Jan 31;508(1-3):239-47. Epub 2005 Jan 12. Erratum in: Eur J Pharmacol. 2005 May 16;515(1-3):188. PubMed PMID: 15680277. |
