FR-217840

• CAT Number: I006882
• CAS Number: 848444-16-6
• Molecular Formula: C16H18FN3O6S3
• Molecular Weight: 463.51
• Purity: ≥95%
• Synonyms: FR-217840; FR217840; FR 217840.;2-Piperazinecarboxamide, 1-((5-(4-fluorophenyl)-2-thienyl)sulfonyl)-N-hydroxy-4-(methylsulfonyl)-, (2S)-
• Target: metalloproteinase inhibitor
• Solubility: Soluble in DMSO
• Storage: 0 - 4°C for short term or -20 °C for long term
• IUPAC Name: (2S)-1-[5-(4-fluorophenyl)thiophen-2-yl]sulfonyl-N-hydroxy-4-methylsulfonylpiperazine-2-carboxamide
• InChI: InChI=1S/C16H18FN3O6S3/c1-28(23,24)19-8-9-20(13(10-19)16(21)18-22)29(25,26)15-7-6-14(27-15)11-2-4-12(17)5-3-11/h2-7,13,22H,8-10H2,1H3,(H,18,21)/t13-/m0/s1
• InChIKey: YFWUVSPVKPCLSA-ZDUSSCGKSA-N
• SMILES: CS(=O)(=O)N1CCN(C(C1)C(=O)NO)S(=O)(=O)C2=CC=C(S2)C3=CC=C(C=C3)F

FR-217840(CAT: I006882) is a potent and selective inhibitor of the interleukin-5 (IL-5) receptor, extensively studied for its role in modulating eosinophilic inflammation. By targeting the IL-5 signaling pathway, it reduces eosinophil activation and recruitment, making it valuable in research on asthma, allergic diseases, and other eosinophil-mediated conditions. FR-217840 is particularly useful in exploring the therapeutic potential of IL-5 receptor inhibition in reducing airway inflammation and hyperresponsiveness. Its specificity and effectiveness provide researchers with a reliable tool for advancing studies on immune regulation and the development of novel treatments for allergic and inflammatory disorders.