FR-218944 free base

• CAT Number: I027766
• CAS Number: 233262-75-4
• Molecular Formula: C27H26N4O3
• Molecular Weight: 454.53
• Purity: 98%
• Synonyms: FR-218944 free base; FR 218944 free base; FR218944 free base
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: Benzamide, 2-methoxy-N-(2-methyl-1H-benzimidazol-7-yl)-4-((2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl)
• InChI: InChI=1S/C27H26N4O3/c1-17-28-21-10-7-11-22(25(21)29-17)30-26(32)20-14-13-19(16-24(20)34-2)27(33)31-15-6-5-9-18-8-3-4-12-23(18)31/h3-4,7-8,10-14,16H,5-6,9,15H2,1-2H3,(H,28,29)(H,30,32)
• InChIKey: GQNJIJVVXIQOQC-UHFFFAOYSA-N
• SMILES: COc1cc(ccc1C(=O)Nc2cccc3nc(C)[nH]c23)C(=O)N4CCCCc5ccccc45

FR-218944 free base (Cat No.: I027766) is a potent and selective endothelin receptor antagonist, primarily targeting the endothelin-A (ETA) receptor. Endothelin-1, acting through ETA receptors, contributes to vasoconstriction, cell proliferation, and inflammation, especially in cardiovascular and renal diseases. FR-218944 blocks this pathway, making it valuable in preclinical studies focused on hypertension, heart failure, and kidney dysfunction. As a free base, it represents the non-salt form of the compound, often used for formulation or chemical modification in drug development and pharmacological research.