FR 900098 Monosodium Salt

• CAT Number: R012371
• CAS Number: 73226-73-0
• Molecular Formula: C5H11NNaO5P
• Molecular Weight: 219.109
• Purity: ≥95%
• Synonyms: P-[3-(Acetylhydroxyamino)propyl]phosphonic Acid Sodium Salt; [3-(Acetylhydroxyamino)propyl]phosphonic Acid Monosodium Salt; Antibiotic FR 900098 Monosodium Salt
• Target: Antibiotic
• Storage: -20°C
• IUPAC Name: sodium;3-[acetyl(hydroxy)amino]propyl-hydroxyphosphinate
• InChI: InChI=1S/C5H12NO5P.Na/c1-5(7)6(8)3-2-4-12(9,10)11;/h8H,2-4H2,1H3,(H2,9,10,11);/q;+1/p-1
• InChIKey: LCFXFDGYDKNWMD-UHFFFAOYSA-M
• SMILES: CC(=O)N(CCCP(=O)(O)[O-])O.[Na+]

FR900098 is a derivative of fosmidomycin (Item No. 16000) that has antimalarial activity (IC50s = 170, 170, and 90 nM for HB3, A2, and Dd2 P. falciparum strains, respectively). FR900098 inhibits DOXP reductoisomerase, a key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis, in vitro in a dose-dependent manner. FR900098 (>10 mg/kg, i.p.) eradicated P. vinckei parasites within four days in mice.