FR900359

• CAT Number: I006908
• CAS Number: 107530-18-7
• Molecular Formula: C49H75N7O15
• Molecular Weight: 1002.173
• Purity: ≥95%
• Synonyms: FR900359; FR 900359; FR-900359.;[(1R)-1-[(3S,6S,9S,12S,18R,21S,22R)-21-acetamido-18-benzyl-3-[(1R)-1-methoxyethyl]-4,9,10,12,16-pentamethyl-15-methylidene-2,5,8,11,14,17,20-heptaoxo-22-propan-2-yl-1,19-dioxa-4,7,10,13,16-pentazacyclodocos-6-yl]-2-met
• Target: Gq-Inhibitor
• Solubility: Soluble in DMSO
• Storage: 0 - 4°C for short term or -20 °C for long term
• IUPAC Name: [(1R)-1-[(3S,6S,9S,12S,18R,21S,22R)-21-acetamido-18-benzyl-3-[(1R)-1-methoxyethyl]-4,9,10,12,16-pentamethyl-15-methylidene-2,5,8,11,14,17,20-heptaoxo-22-propan-2-yl-1,19-dioxa-4,7,10,13,16-pentazacyclodocos-6-yl]-2-methylpropyl] (2S,3R)-3-hydroxy-4-methyl-2-(propanoylamino)pentanoate
• InChI: InChI=1S/C49H75N7O15/c1-17-34(58)52-35(39(59)24(2)3)47(65)70-40(25(4)5)36-46(64)56(15)38(30(11)68-16)49(67)71-41(26(6)7)37(51-31(12)57)48(66)69-33(23-32-21-19-18-20-22-32)45(63)55(14)28(9)42(60)50-27(8)44(62)54(13)29(10)43(61)53-36/h18-22,24-27,29-30,33,35-41,59H,9,17,23H2,1-8,10-16H3,(H,50,60)(H,51,57)(H,52,58)(H,53,61)/t27-,29-,30+,33+,35-,36-,37-,38-,39+,40+,41+/m0/s1
• InChIKey: IMXKHFILKMPFGB-ZWYWTTNJSA-N
• SMILES: CCC(=O)NC(C(C(C)C)O)C(=O)OC(C1C(=O)N(C(C(=O)OC(C(C(=O)OC(C(=O)N(C(=C)C(=O)NC(C(=O)N(C(C(=O)N1)C)C)C)C)CC2=CC=CC=C2)NC(=O)C)C(C)C)C(C)OC)C)C(C)C

FR900359 (also known as FR or FRα) is a potent inhibitor of the Gq protein family, which plays a crucial role in cellular signaling pathways. It is a cyclic depsipeptide originally isolated from the bacterium Ardisia crenata. FR900359 is known for its ability to specifically inhibit the activation of Gq proteins, thereby blocking downstream signaling pathways that are implicated in various physiological and pathological processes, including cancer, cardiovascular diseases, and inflammation. Due to its high specificity and efficacy, FR900359 has become an important tool in research aimed at understanding Gq protein functions and developing potential therapeutic strategies targeting Gq-mediated signaling pathways.