FRAX597 Hydrochloride

• CAT Number: I012625
• CAS Number: 1428758-85-3
• Molecular Formula: C29H29Cl2N7OS
• Molecular Weight: 594.56
• Purity: ≥95%
• Synonyms: 6-[2-Chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-Pyrido[2,3-d]pyrimidin-7(8H)-one Hydrochloride
• IUPAC Name: 6-[2-chloro-4-(1,3-thiazol-5-yl)phenyl]-8-ethyl-2-[4-(4-methylpiperazin-1-yl)anilino]pyrido[2,3-d]pyrimidin-7-one;hydrochloride
• InChI: InChI=1S/C29H28ClN7OS.ClH/c1-3-37-27-20(14-24(28(37)38)23-9-4-19(15-25(23)30)26-17-31-18-39-26)16-32-29(34-27)33-21-5-7-22(8-6-21)36-12-10-35(2)11-13-36;/h4-9,14-18H,3,10-13H2,1-2H3,(H,32,33,34);1H
• InChIKey: VMGGCECGUUCYOI-UHFFFAOYSA-N
• SMILES: CCN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=C(C=C3)C4=CN=CS4)Cl)NC5=CC=C(C=C5)N6CCN(CC6)C.Cl

FRAX597 Hydrochloride (Cat No.: I012625) is a potent, selective inhibitor of p21-activated kinases (PAKs), particularly PAK1, PAK2, and PAK3. By targeting these kinases, it disrupts key signaling pathways involved in cytoskeletal dynamics, cell migration, and survival. FRAX597 is widely studied in cancer research for its potential to inhibit tumor progression and metastasis. Additionally, it has applications in neurological disease research, particularly in neurodegenerative disorders and neurodevelopmental conditions. As a PAK inhibitor, FRAX597 Hydrochloride serves as a valuable tool in therapeutic target validation.