Frentizole

• CAT Number: I002893
• CAS Number: 26130-02-9
• Molecular Formula: C15H13N3O2S
• Molecular Weight: 299.35
• Purity: ≥95%
• Synonyms: LY 53616; LY53616; LY-53616; Frentizole
• Target: Amyloid-β
• Solubility: DMSO: ≥ 3 mg/mL
• Storage: Store at -20°C
• InChI: InChI=1S/C15H13N3O2S/c1-20-11-7-8-12-13(9-11)21-15(17-12)18-14(19)16-10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19)
• InChIKey: O=C(NC1=CC=CC=C1)NC2=NC3=CC=C(OC)C=C3S2

Frentizole(CAT: I002893), also known as LY 53616, is an immunosuppressive agent. Frentizole was more effective in suppressing human lymphocytes responding to Con A and PWM, than it was in cells activated by PHA, specific antigen, or alloantigen. Methylprednisolone, on the other hand, was more inhibitory for cells stimulated by PHA, specific antigen, or alloantigen. Frentizole, even at super immunosuppressive doses, does not predispose the hose (mice) to Pseudomonas aeruginosa, Candida albicans, herpes simplex virus, or Ann Arbor influenza virus.

Reference

1. J Immunopharmacol. 1979;1(4):483-95.

Effect of frentizole on mitogen-induced blastogenesis in human lymphocytes.

Meisel AD(1), Bush M, Ginzler E, Diamond HS.

Author information:
(1)State University of New York, Downstate Medical Center, Brooklyn 11203.

Frentizole is a new immunoregulatory agent developed as an alternative to
cytotoxic agents. In human lymphocytes, Frentizole inhibits the response to
various phytomitogens without decreasing cell viability. Frentizole (500 ng/ml)
inhibited thymidine incorporation into DNA most effectively when added to
lymphocyte cultures at the same time as the addition of the mitogen. Frentizole
(500 ng/ml) markedly inhibited the response to Con A (% inhibition, corporation
was dose dependent with 125 ng/ml of Frentizole sufficient to inhibit
significantly the response of all three mitogens. Frentizole (62.5 ng/ml)
maximally inhibited uridine incorporation, and inhibition of uridine
incorporation was independent of the phytomitogen employed. Increasing
concentrations of Frentizole were found to have no effect on thymidine or uridine
incorporation into unstimulated normal lymphocytes.

2. Infect Immun. 1977 Jan;15(1):145-8.

Frentizole, a novel immunosuppressive, and azathioprine: their comparative
effects on host resistance to Pseudomonas aeruginosa, Candida albicans, herpes
simplex virus, and influenza (Ann Arbor) virus.

Scheetz ME II, Carlson DG, Schinitsky MR.

Frentizole, 1-(6-methoxy-2-benzothiazolyl)-3-phenyl urea, a new immunosuppressive
agent, and azathioprine were administered subcutaneously at predetermined
immunosuppressive dose levels of azathioprine and up to 50 times an
immunosuppressive dose level of Frentizole. After 10 days of treatment at these
dose levels, the experimental groups were inoculated intraperitoneally with
Pseudomonas aeruginosa or herpes simplex virus, inoculated intraveneously with
Candida albicans, or infected by aerosol with Ann Arbor influenza virus. The
results of these series of experiments indicate that Frentizole, even at super
immunosuppressive doses, does not predispose the hose (mice) to Pseudomonas
aeruginosa, Candida albicans, herpes simplex virus, or Ann Arbor influenza virus.