For research use only. Not for therapeutic Use.
FSG67 is a glycerol 3-phosphate acyltransferase (GPAT) inhibitor with an IC50 of 24 μM[1].
FSG67 reduces GSK3β phosphorylation and signaling after acetaminophen overdose[1].
FSG67 results in a dose-dependent increase in oxidative metabolism in mature adipocytes with an IC50 of 27.7 ± 4.4 μM[2].
| Catalog Number | I043596 |
| CAS Number | 1158383-34-6 |
| Synonyms | 2-(nonylsulfonylamino)benzoic acid |
| Molecular Formula | C16H25NO4S |
| Purity | ≥95% |
| InChI | InChI=1S/C16H25NO4S/c1-2-3-4-5-6-7-10-13-22(20,21)17-15-12-9-8-11-14(15)16(18)19/h8-9,11-12,17H,2-7,10,13H2,1H3,(H,18,19) |
| InChIKey | WNFXEGWGYFRRJC-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCS(=O)(=O)NC1=CC=CC=C1C(=O)O |
| Reference | [1]. Clemens MM, et al. The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling. Food Chem Toxicol. 2019 Mar;125:279-288. [2]. Reilly SM, et al. Catecholamines suppress fatty acid re-esterification and increase oxidation in white adipocytes via STAT3. Nat Metab. 2020 Jul;2(7):620-634. |
