For research use only. Not for therapeutic Use.
FT709 is a potent and selective USP9X inhibitor, an IC50 of 82 nM. USP9X has been linked with centrosome function, chromosome alignment during mitosis, EGF receptor degradation, chemo-sensitization, and circadian rhythms[1].
FT709 (10 µM, 24 h) decreases levels of ZNF598 (ubiquitin E3 ligase) and the centrosomal protein CEP55 in HCT116 cells[1].
| Catalog Number | I043837 |
| CAS Number | 2413991-74-7 |
| Synonyms | (2S)-1-[5-(2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-7-ylsulfonyl)-1,3,4,6-tetrahydropyrrolo[3,4-c]pyrrol-2-yl]-2-hydroxy-2-(2-methyl-1,3-benzoxazol-4-yl)ethanone |
| Molecular Formula | C23H22N4O7S |
| Purity | ≥95% |
| InChI | InChI=1S/C23H22N4O7S/c1-13-25-20-17(3-2-4-18(20)34-13)21(28)23(29)26-9-14-11-27(12-15(14)10-26)35(30,31)16-7-19-22(24-8-16)33-6-5-32-19/h2-4,7-8,21,28H,5-6,9-12H2,1H3/t21-/m0/s1 |
| InChIKey | SCFWBZTVFCUBIZ-NRFANRHFSA-N |
| SMILES | CC1=NC2=C(C=CC=C2O1)C(C(=O)N3CC4=C(C3)CN(C4)S(=O)(=O)C5=CC6=C(N=C5)OCCO6)O |
| Reference | [1]. Clancy A, et, al. The deubiquitylase USP9X controls ribosomal stalling. J Cell Biol. 2021 Mar 1;220(3):e202004211. |
