For research use only. Not for therapeutic Use.
FT895 is a potent and selective HDAC11 inhibitor with an IC50 of 3 nM[1].
FT895 is a highly selective HDAC11 inhibitor showing greater than 1000-fold selectivity against the other 10 members of the HDAC family[1].
| Catalog Number | I019370 |
| CAS Number | 2225728-57-2 |
| Synonyms | N-hydroxy-1,1-dimethyl-2-[5-(trifluoromethyl)pyrazin-2-yl]-3H-isoindole-4-carboxamide |
| Molecular Formula | C16H15F3N4O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H15F3N4O2/c1-15(2)11-5-3-4-9(14(24)22-25)10(11)8-23(15)13-7-20-12(6-21-13)16(17,18)19/h3-7,25H,8H2,1-2H3,(H,22,24) |
| InChIKey | XCLPBILTRRWOIL-UHFFFAOYSA-N |
| SMILES | CC1(C2=CC=CC(=C2CN1C3=NC=C(N=C3)C(F)(F)F)C(=O)NO)C |
| Reference | [1]. Martin MW, et al. Discovery of novel N-hydroxy-2-arylisoindoline-4-carboxamides as potent and selective inhibitors of HDAC11. Bioorg Med Chem Lett. 2018 Jul 1;28(12):2143-2147. |
