FTI 276 TFA

• CAT Number: I019104
• CAS Number: 1217471-51-6
• Molecular Formula: C₂₃H₂₈F₃N₃O₅S₂
• Molecular Weight: 547.61
• Purity: ≥95%
• Target: Farnesyl Transferase
• IUPAC Name: (2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropyl]amino]-2-phenylbenzoyl]amino]-4-methylsulfanylbutanoic acid;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C21H27N3O3S2.C2HF3O2/c1-29-10-9-19(21(26)27)24-20(25)17-8-7-16(23-12-15(22)13-28)11-18(17)14-5-3-2-4-6-14;3-2(4,5)1(6)7/h2-8,11,15,19,23,28H,9-10,12-13,22H2,1H3,(H,24,25)(H,26,27);(H,6,7)/t15-,19+;/m1./s1
• InChIKey: IAVHISGQCODLHL-WSCVZUBPSA-N
• SMILES: CSCC[C@@H](C(=O)O)NC(=O)C1=C(C=C(C=C1)NC[C@H](CS)N)C2=CC=CC=C2.C(=O)(C(F)(F)F)O

FTI 276 TFA (Cat.No:I019104) is a specific farnesyltransferase inhibitor (FTI) that targets the enzyme responsible for adding a farnesyl group to proteins. By inhibiting farnesylation, FTI 276 TFA interferes with the signaling pathways involved in cell growth and proliferation, showing potential for anticancer therapy. Further research is ongoing to explore its therapeutic applications.

Reference

[1]. Chakrabarti D, et al. Protein farnesyltransferase and protein prenylation in Plasmodium falciparum.J Biol Chem. 2002 Nov 1; 277(44):42066-73. Epub 2002 Aug 22.