For research use only. Not for therapeutic Use.
FTI 277 HCl(Cat No.:I002351), the methyl ester of FTI 277, is a highly potent and selective inhibitor of farnesyltransferase (FTase), an enzyme involved in post-translational protein modification. With an impressive IC50 value of 500 pM, it exhibits remarkable inhibitory activity against FTase. Notably, FTI 277 HCl demonstrates a high level of selectivity, being 100-fold more specific for FTase than for the closely related enzyme geranylgeranyltransferase I (GGTase I). This selective inhibition of FTase makes FTI 277 HCl a promising candidate for targeted therapy and research in diseases related to aberrant protein farnesylation.
Catalog Number | I002351 |
CAS Number | 180977-34-8 |
Synonyms | (Z)-5-(((R)-2-amino-3-mercaptopropyl)amino)-N-((S)-1-methoxy-4-(methylthio)-1-oxobutan-2-yl)-[1,1/’-biphenyl]-2-carbimidic acid hydrochloride |
Molecular Formula | C₂₂H₂₉N₃O₃S₂.HCl |
Purity | ≥95% |
Target | Apoptosis |
Solubility | DMSO: ≥ 4.7 mg/mL |
Storage | 2-8°C |
IUPAC Name | methyl (2S)-2-[[4-[[(2R)-2-amino-3-sulfanylpropyl]amino]-2-phenylbenzoyl]amino]-4-methylsulfanylbutanoate;hydrochloride |
InChI | InChI=1S/C22H29N3O3S2.ClH/c1-28-22(27)20(10-11-30-2)25-21(26)18-9-8-17(24-13-16(23)14-29)12-19(18)15-6-4-3-5-7-15;/h3-9,12,16,20,24,29H,10-11,13-14,23H2,1-2H3,(H,25,26);1H/t16-,20+;/m1./s1 |
InChIKey | PIAFFJUUNXEDEW-PXPMWPIZSA-N |
SMILES | COC(=O)C(CCSC)NC(=O)C1=C(C=C(C=C1)NCC(CS)N)C2=CC=CC=C2.Cl |
Reference | <p style=/line-height:25px/> |