For research use only. Not for therapeutic Use.
FTO-04 is a novel fat mass- and obesity-associated protein (FTO) inhibitor, preventing neurosphere formation in patient-derived glioblastoma stem cells (GSCs) without inhibiting the growth of healthy neural stem cell-derived neurospheres.
| Catalog Number | I027817 |
| Synonyms | FTO-04; FTO04; FTO 04; |
| Molecular Formula | C12H10N4OS |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 6-(2-methoxypyrimidin-5-yl)benzo[d]thiazol-2-amine |
| InChI | InChI=1S/C12H10N4OS/c1-17-12-14-5-8(6-15-12)7-2-3-9-10(4-7)18-11(13)16-9/h2-6H,1H3,(H2,13,16) |
| InChIKey | POOYWDOOHWPQCU-UHFFFAOYSA-N |
| SMILES | NC1=NC2=CC=C(C3=CN=C(OC)N=C3)C=C2S1 |
| Reference | 1: Huff S, Tiwari SK, Gonzalez GM, Wang Y, Rana TM. m6A-RNA Demethylase FTO Inhibitors Impair Self-Renewal in Glioblastoma Stem Cells. ACS Chem Biol. 2021 Jan 7. doi: 10.1021/acschembio.0c00841. Epub ahead of print. PMID: 33412003. |
