FTO-IN-1 TFA

• CAT Number: I044468
• CAS Number: 2797619-81-7
• Molecular Formula: C20H17Cl2F3N4O4
• Molecular Weight: 505.27
• Purity: ≥95%
• Synonyms: 2-[2,6-dichloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)anilino]-N-hydroxybenzamide;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C18H16Cl2N4O2.C2HF3O2/c1-9-16(10(2)23-22-9)11-7-13(19)17(14(20)8-11)21-15-6-4-3-5-12(15)18(25)24-26;3-2(4,5)1(6)7/h3-8,21,26H,1-2H3,(H,22,23)(H,24,25);(H,6,7)
• InChIKey: QHFDCFXIEHIDKJ-UHFFFAOYSA-N
• SMILES: CC1=C(C(=NN1)C)C2=CC(=C(C(=C2)Cl)NC3=CC=CC=C3C(=O)NO)Cl.C(=O)(C(F)(F)F)O

FTO-IN-1 TFA is a fat mass and obesity-associated enzyme (FTO) inhibitor extracted from patent WO2018157843A1, compound 32, with an IC50 of <1 μM. FTO-IN-1 TFA can be used for the research of cancer[1].
FTO-IN-1 TFA (50 μM) inhibits FTO enzyme activity by 62% in vitro[1].
FTO-IN-1 TFA (50 μM) inhibits the viability of SCLC-21H, RH30 and KP3 cells, with IC50s of 2.1 μM, 5.3 μM, and 5.6 μM, respectively[1].

Reference

[1]. Yang C, et, al. 2-(substituted benzene matrix) aromatic formate fto inhibitor, preparation method therefor, and applications thereof. WO2018157843A1.