For research use only. Not for therapeutic Use.
FTO-IN-8 (FTO-43) is a N6-methyladenosine demethylase (FTO) (fat mass- and obesity-associated protein) inhibitor with the IC50 value of 5.5 μM. FTO-IN-8 has anti-cancer cell proliferative activity[1].
FTO-IN-8 (FTO-43) (0-50 μM, 24-72 h) inhibits the proliferation of cancer cells with no cytotoxicity to normal colonic cells[1].
FTO-IN-8 (FTO-43) can increase m6A and m6Am levels and inhibits Wnt/PI3K-Akt signaling in gastric cancer AGS cells[1].
| Catalog Number | I043305 |
| CAS Number | 2640366-38-5 |
| Synonyms | 1-[5-(2-chlorophenyl)furan-2-yl]-N-[(3-pyrrolidin-1-yloxetan-3-yl)methyl]methanamine |
| Molecular Formula | C19H23ClN2O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H23ClN2O2/c20-17-6-2-1-5-16(17)18-8-7-15(24-18)11-21-12-19(13-23-14-19)22-9-3-4-10-22/h1-2,5-8,21H,3-4,9-14H2 |
| InChIKey | QHNARTNMADDQGU-UHFFFAOYSA-N |
| SMILES | C1CCN(C1)C2(COC2)CNCC3=CC=C(O3)C4=CC=CC=C4Cl |
| Reference | [1]. Sarah Huff, et al. Rational Design and Optimization of m6A-RNA Demethylase FTO Inhibitors as Anticancer Agents. J Med Chem. 2022 Aug 8. |
