Fudosteine

• CAT Number: A001034
• CAS Number: 13189-98-5
• Molecular Formula: C6H13NO3S
• Molecular Weight: 179.2
• Purity: ≥95%
• Synonyms: 13189-98-5; Cleanal; S-(3-Hydroxypropyl)-L-cysteine; S-(3-Hydroxypropyl)cysteine; L-Cysteine, S-(3-hydroxypropyl)-
• Target: MUC5AC Mucin Hypersecretion Inhibitor
• Storage: -20°C
• InChI: 1S/C6H13NO3S/c7-5(6(9)10)4-11-3-1-2-8/h5,8H,1-4,7H2,(H,9,10)/t5-/m0/s1
• InChIKey: KINWYTAUPKOPCQ-YFKPBYRVSA-N
• SMILES: C(CO)CSCC(C(=O)O)N

Fudosteine, also known as Cleanal and SS-320A, is a MUC5AC mucin hypersecretion inhibitor that is used as an expectorant in chronic bronchial inflammatory disorders.

Reference

1: Gooty AR, Katreddi HR, S RR, Hunnur RK, Sharma HK, Masani NK. Simultaneous
Determination of Genotoxic Impurities in Fudosteine Drugs by GC-MS. J Chromatogr
Sci. 2016 Sep;54(8):1277-81. doi: 10.1093/chromsci/bmw070. Epub 2016 Jun 3.
PubMed PMID: 27261527.

2: Fan PC, Ren J, Ma HP, Jing LL, Ma J, Jia ZP. Liquid Chromatography Tandem
Mass/Mass Spectrometry for the Quantification of Fudosteine in Human Serum
without Precolumn Derivatization. Iran J Pharm Res. 2014 Spring;13(2):441-7.
PubMed PMID: 25237339; PubMed Central PMCID: PMC4157019.

3: Ueno-Iio T, Shibakura M, Iio K, Tanimoto Y, Kanehiro A, Tanimoto M, Kataoka M.
Effect of fudosteine, a cysteine derivative, on airway hyperresponsiveness,
inflammation, and remodeling in a murine model of asthma. Life Sci. 2013 May
30;92(20-21):1015-23. doi: 10.1016/j.lfs.2013.03.022. Epub 2013 Apr 10. PubMed
PMID: 23583570.

4: Osoata GO, Hanazawa T, Brindicci C, Ito M, Barnes PJ, Kharitonov S, Ito K.
Peroxynitrite elevation in exhaled breath condensate of COPD and its inhibition
by fudosteine. Chest. 2009 Jun;135(6):1513-1520. doi: 10.1378/chest.08-2105. Epub
2009 Feb 2. PubMed PMID: 19188555.

5: Antonela Antoniu S. Fudosteine effects on mucin production. Expert Opin
Investig Drugs. 2009 Jan;18(1):105-7. doi: 10.1517/13543780802623863 . PubMed
PMID: 19053887.

6: Rhee CK, Kang CM, You MB, Yoon HK, Kim YK, Kim KH, Moon HS, Park SH, Song JS.
Effect of fudosteine on mucin production. Eur Respir J. 2008 Nov;32(5):1195-202.
doi: 10.1183/09031936.00018508. Epub 2008 Jun 25. PubMed PMID: 18579549.

7: Wen J, Wu Y, Zhang L, Qi Y, Fan G, Wu Y, Li Z. High-throughput determination
of fudosteine in human plasma by liquid chromatography-tandem mass spectrometry,
following protein precipitation in the 96-well plate format. J Chromatogr B
Analyt Technol Biomed Life Sci. 2008 May 1;867(1):153-9. doi:
10.1016/j.jchromb.2008.03.017. Epub 2008 Mar 29. PubMed PMID: 18407809.

8: Jiao HY, Zhang ZJ, Xu FG, Tian Y, Zhang BB, Chen Y. The pharmacokinetics of
orally administered fudosteine in healthy Chinese volunteers. Eur J Drug Metab
Pharmacokinet. 2006 Apr-Jun;31(2):65-71. PubMed PMID: 16898073.

9: Xu F, Zhang Z, Jiao H, Tian Y, Zhang B, Chen Y. Quantification of fudosteine
in human plasma by high-performance liquid chromatography-electrospray ionization
mass spectrometry employing precolumn derivatization with 9-fluorenylmethyl
chloroformate. J Mass Spectrom. 2006 May;41(5):685-92. PubMed PMID: 16598709.

10: Ding L, Yang J, Li RS, Zhou M, Shen JP, Zhang YD. [Pharmacokinetics of
fudosteine in healthy volunteers]. Yao Xue Xue Bao. 2005 Oct;40(10):945-9.
Chinese. PubMed PMID: 16408815.