Fumagillin（Cat No.:A000104）is a potent antimicrobial agent derived from the fungus Aspergillus fumigatus. It is primarily used to treat microsporidiosis, an infection caused by microsporidia, particularly in beekeeping to control Nosema disease. Fumagillin’s mechanism involves inhibiting the enzyme methionine aminopeptidase 2 (MetAP2), leading to suppression of cell growth and angiogenesis. This compound is significant in veterinary medicine and has potential applications in cancer research due to its anti-angiogenic properties. Fumagillin’s efficacy and specificity make it a valuable tool in both agricultural and medical fields.
| Catalog Number | A000104 |
| CAS Number | 23110-15-8 |
| Synonyms | NA |
| Molecular Formula | C₂₆H₃₄O₇ |
| Purity | 95% |
| Target | Aminopeptidase |
| Solubility | Soluble to 3 mM in ethanol |
| Storage | Store at -20°C |
| IUPAC Name | (2E,4E,6E,8E)-10-[[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid |
| InChI | InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+/t19-,20-,23-,24-,25+,26+/m1/s1 |
| InChIKey | NGGMYCMLYOUNGM-CSDLUJIJSA-N |
| SMILES | CC(=CCC1C(O1)(C)C2C(C(CCC23CO3)OC(=O)C=CC=CC=CC=CC(=O)O)OC)C |
