Fumagillin

  • CAT Number: A000104
  • CAS Number: 23110-15-8
  • Molecular Formula: C₂₆H₃₄O₇
  • Molecular Weight: 458.54
  • Purity: ≥95%
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Fumagillin(Cat No.:A000104)is a potent antimicrobial agent derived from the fungus Aspergillus fumigatus. It is primarily used to treat microsporidiosis, an infection caused by microsporidia, particularly in beekeeping to control Nosema disease. Fumagillin’s mechanism involves inhibiting the enzyme methionine aminopeptidase 2 (MetAP2), leading to suppression of cell growth and angiogenesis. This compound is significant in veterinary medicine and has potential applications in cancer research due to its anti-angiogenic properties. Fumagillin’s efficacy and specificity make it a valuable tool in both agricultural and medical fields.


Catalog Number A000104
CAS Number 23110-15-8
Synonyms

NA

Molecular Formula C₂₆H₃₄O₇
Purity ≥95%
Target Aminopeptidase
Solubility Soluble to 3 mM in ethanol
Storage Store at -20°C
IUPAC Name (2E,4E,6E,8E)-10-[[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid
InChI InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+/t19-,20-,23-,24-,25+,26+/m1/s1
InChIKey NGGMYCMLYOUNGM-CSDLUJIJSA-N
SMILES CC(=CCC1C(O1)(C)C2C(C(CCC23CO3)OC(=O)C=CC=CC=CC=CC(=O)O)OC)C

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