For research use only. Not for therapeutic Use.
Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor. Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2.2 μM[1].
Fumarate hydratase-IN-1 inhibits SW620, ACHN, HCT-116, PC3, and SK-MEL-28 cell lines with a mean IC50 of 2.2 μM[1].
| Catalog Number | I002150 |
| CAS Number | 1644060-37-6 |
| Synonyms | ethyl (3S,3aR)-3-[2-(methylamino)-2-oxoethyl]-2-oxo-1-[(4-phenylphenyl)methyl]-3,4,5,6-tetrahydroindole-3a-carboxylate |
| Molecular Formula | C27H30N2O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C27H30N2O4/c1-3-33-26(32)27-16-8-7-11-23(27)29(25(31)22(27)17-24(30)28-2)18-19-12-14-21(15-13-19)20-9-5-4-6-10-20/h4-6,9-15,22H,3,7-8,16-18H2,1-2H3,(H,28,30)/t22-,27-/m1/s1 |
| InChIKey | VFGLXHHVYNTCPD-AJTFRIOCSA-N |
| SMILES | CCOC(=O)C12CCCC=C1N(C(=O)C2CC(=O)NC)CC3=CC=C(C=C3)C4=CC=CC=C4 |
| Reference | [1]. Takeuchi T et al. Identification of Fumarate Hydratase Inhibitors with Nutrient-Dependent Cytotoxicity. J Am Chem Soc, 2015 Jan 21, 137(2): 564-567. |
