Fumitremorgin C

• CAT Number: R040880
• CAS Number: 118974-02-0
• Molecular Formula: C22H25N3O3
• Molecular Weight: 379.45
• Purity: ≥95%
• Synonyms: (5aS,12S,14aS)-1,2,3,5a,6,11,12,14a-Octahydro-9-methoxy-12-(2-methyl-1-propen-1-yl)-5H,14H-pyrrolo[1’’,2’’:4’,5’]pyrazino[1’,2’:1,6]pyrido[3,4-b]indole-5,14-dione
• Target: Anti-infection
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at +4℃
• IUPAC Name: (1S,12S,15S)-7-methoxy-12-(2-methylprop-1-enyl)-10,13,19-triazapentacyclo[11.7.0.03,11.04,9.015,19]icosa-3(11),4(9),5,7-tetraene-14,20-dione
• InChI: InChI=1S/C22H25N3O3/c1-12(2)9-18-20-15(14-7-6-13(28-3)10-16(14)23-20)11-19-21(26)24-8-4-5-17(24)22(27)25(18)19/h6-7,9-10,17-19,23H,4-5,8,11H2,1-3H3/t17-,18-,19-/m0/s1
• InChIKey: DBEYVIGIPJSTOR-FHWLQOOXSA-N
• SMILES: CC(=CC1C2=C(CC3N1C(=O)C4CCCN4C3=O)C5=C(N2)C=C(C=C5)OC)C

Fumitremorgin C(CAS118974-02-0) is a mycotoxin and bioactive compound produced by certain Aspergillus and Penicillium species. It is widely studied for its role as a potent and selective inhibitor of ATP-binding cassette (ABC) transporters, particularly ABCG2 (Breast Cancer Resistance Protein, BCRP). This property makes it valuable in cancer research for understanding multidrug resistance mechanisms. Additionally, Fumitremorgin C’s structural complexity and biological activity contribute to studies in fungal metabolism and natural product chemistry, offering insights into potential therapeutic applications and toxin management.