For research use only. Not for therapeutic Use.
Funapide, aslo known as TV-45070 and XEN402, is a novel analgesic agent which may be useful for the treatment of a variety of chronic pain conditions, including osteoarthritis, neuropathic pain, postherpetic neuralgia, and erythromelalgia, as well as dental pain. Funapide acts as a small-molecule Nav1.7 and Nav1.8 voltage-gated sodium channel blocker.
| Catalog Number | R029865 |
| CAS Number | 1259933-16-8 |
| Synonyms | (3’S)-1’-[[5-(Trifluoromethyl)-2-furanyl]methyl]-spiro[furo[2,3-f]-1,3-benzodioxole-7(6H),3’-[3H]indol]-2’(1’H)-one |
| Molecular Formula | C22H14F3NO5 |
| Purity | ≥95% |
| Target | Sodium Channel |
| Storage | Store at -20°C |
| IUPAC Name | (7S)-1/'-[[5-(trifluoromethyl)furan-2-yl]methyl]spiro[6H-furo[2,3-f][1,3]benzodioxole-7,3/'-indole]-2/'-one |
| InChI | InChI=1S/C22H14F3NO5/c23-22(24,25)19-6-5-12(31-19)9-26-15-4-2-1-3-13(15)21(20(26)27)10-28-16-8-18-17(7-14(16)21)29-11-30-18/h1-8H,9-11H2/t21-/m0/s1 |
| InChIKey | NEBUOXBYNAHKFV-NRFANRHFSA-N |
| SMILES | C1C2(C3=CC=CC=C3N(C2=O)CC4=CC=C(O4)C(F)(F)F)C5=CC6=C(C=C5O1)OCO6 |
| Reference | </br>1: Bagal SK, Chapman ML, Marron BE, Prime R, Storer RI, Swain NA. Recent progress</br> in sodium channel modulators for pain. Bioorg Med Chem Lett. 2014 Aug</br> 15;24(16):3690-9. doi: 10.1016/j.bmcl.2014.06.038. Epub 2014 Jun 21. Review.</br> PubMed PMID: 25060923.</br>2: Goldberg YP, Pimstone SN, Namdari R, Price N, Cohen C, Sherrington RP, Hayden </br> MR. Human Mendelian pain disorders: a key to discovery and validation of novel</br> analgesics. Clin Genet. 2012 Oct;82(4):367-73. doi:</br> 10.1111/j.1399-0004.2012.01942.x. Epub 2012 Aug 13. Review. PubMed PMID:</br> 22845492.</br>3: Goldberg YP, Price N, Namdari R, Cohen CJ, Lamers MH, Winters C, Price J,</br> Young CE, Verschoof H, Sherrington R, Pimstone SN, Hayden MR. Treatment of</br> Na(v)1.7-mediated pain in inherited erythromelalgia using a novel sodium channel </br> blocker. Pain. 2012 Jan;153(1):80-5. doi: 10.1016/j.pain.2011.09.008. Epub 2011</br> Oct 28. PubMed PMID: 22035805.</br>4: Mai G, del Rio ML, Tian J, Ramirez P, Buhler L, Rodriguez-Barbosa JI. Blockade</br> of the PD-1/PD-1L pathway reverses the protective effect of anti-CD40L therapy in</br> a rat to mouse concordant islet xenotransplantation model. Xenotransplantation.</br> 2007 May;14(3):243-8. PubMed PMID: 17489865.</br></br> |
