For research use only. Not for therapeutic Use.
Fura-2 pentapotassium is a scaled fluorescent dye that can be used for intracellular calcium imaging with the Kd value of 140 nM. Fura-2 pentapotassium has an emission wavelength of 510 nm and excitation wavelengths of 340 nm or 380 nm and the ratio of 340/380 fluorescence intensity is proportional to the intracellular Ca2+ level[1][2].
Fura-2 pentapotassium (10 μM, 2 min) can be used to detect changes in the concentration of calcium ions in neutrophils of heparinized peripheral blood[1].
Fura-2 pentapotassium (10 μM, 5 min) can be used as a calcium probe to assess the distribution of calcium ions within heart mitochondria without affecting the activity of it in rat[2].
| Catalog Number | R001089 |
| CAS Number | 113694-64-7 |
| Synonyms | pentapotassium;2-[6-[bis(carboxylatomethyl)amino]-5-[2-[2-[bis(carboxylatomethyl)amino]-5-methylphenoxy]ethoxy]-1-benzofuran-2-yl]-1,3-oxazole-5-carboxylate |
| Molecular Formula | C29H22K5N3O14 |
| Purity | ≥95% |
| InChI | InChI=1S/C29H27N3O14.5K/c1-15-2-3-17(31(11-24(33)34)12-25(35)36)20(6-15)43-4-5-44-21-7-16-8-22(28-30-10-23(46-28)29(41)42)45-19(16)9-18(21)32(13-26(37)38)14-27(39)40;;;;;/h2-3,6-10H,4-5,11-14H2,1H3,(H,33,34)(H,35,36)(H,37,38)(H,39,40)(H,41,42);;;;;/q;5*+1/p-5 |
| InChIKey | HQKWBBCTCLUGSX-UHFFFAOYSA-I |
| SMILES | CC1=CC(=C(C=C1)N(CC(=O)[O-])CC(=O)[O-])OCCOC2=C(C=C3C(=C2)C=C(O3)C4=NC=C(O4)C(=O)[O-])N(CC(=O)[O-])CC(=O)[O-].[K+].[K+].[K+].[K+].[K+] |
| Reference | [1]. Omar Rafael Alemán, et al. The Antibody Receptor Fc Gamma Receptor IIIb Induces Calcium Entry via Transient Receptor Potential Melastatin 2 in Human Neutrophils. Front Immunol. 2021 May 13;12:657393. doi: 10.3389/fimmu.2021.657393. [2]. James G. McCormack, et al. Studies on mitochondrial Ca2+-transport and matrix Ca2+ using fura-2-loaded rat heart mitochondria. Biochim Biophys Acta. 1989 Mar 23;973(3):420-7. |
