For research use only. Not for therapeutic Use.
Furagin（Cat No.:I002186）, also known as Furazidin, is a nitrofuran-based antimicrobial agent primarily used to treat urinary tract infections caused by Gram-positive and Gram-negative bacteria. It works by inhibiting bacterial enzymes involved in DNA synthesis, leading to impaired cellular function and bacterial death. Furagin is valued for its localized action in the urinary tract, minimizing systemic side effects. It is effective against strains resistant to other antibiotics, offering a targeted approach for managing recurrent UTIs. Furagin’s efficacy and specific action make it a common choice in urological infection treatment.
| Catalog Number | I002186 |
| CAS Number | 1672-88-4 |
| Synonyms | 1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione |
| Molecular Formula | C10H8N4O5 |
| Purity | ≥95% |
| Target | Antibiotic |
| Solubility | DMSO:33mg/mL |
| Storage | Store at -20°C |
| IUPAC Name | 1-[(E)-[(E)-3-(5-nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione |
| InChI | InChI=1S/C10H8N4O5/c15-8-6-13(10(16)12-8)11-5-1-2-7-3-4-9(19-7)14(17)18/h1-5H,6H2,(H,12,15,16)/b2-1+,11-5+ |
| InChIKey | DECBQELQORZLLP-UAIOPKHMSA-N |
| SMILES | C1C(=O)NC(=O)N1N=CC=CC2=CC=C(O2)[N+](=O)[O-] |
| Reference | </br>1:Ciprofloxacin and furagin in acute cystitis: comparison of early immune and microbiological results. Dybowski B, Jabłońska O, Radziszewski P, Gromadzka-Ostrowska J, Borkowski A.Int J Antimicrob Agents. 2008 Feb;31(2):130-4. Epub 2007 Dec 3. PMID: 18060746 </br>2:Cytogenetic analysis of children under long-term antibacterial therapy with nitroheterocyclic compound furagin. Slapsyte G, Jankauskiene A, Mierauskiene J, Lazutka JR.Mutat Res. 2001 Apr 5;491(1-2):25-30. PMID: 11287294 </br>3:[Pulmonary reaction after furazidin (Furagin). Case report]. Zielonka TM, Demkow U, Kuś J.Pol Arch Med Wewn. 1997 May;97(5):465-72. Polish. PMID: 9411425 </br>4:[Photosensitizing properties and antioxidant activity of furagin–an antimicrobial drug that is a derivative of nitrofuran]. Makareeva EN, Lozovskaia EL, Tatikolov AS, Sapezhinskiĭ II.Biofizika. 1997 Mar-Apr;42(2):472-9. Russian. PMID: 9172693 </br>5:[Action of furagin, nystatin and levorin with bile acids on the vaginal microflora of pregnant women]. Kuchuma ZN.Vrach Delo. 1986 Oct;(10):10-3. Russian. No abstract available. PMID: 3798871 </br>6:[Combined effect of benzylpenicillin, furagin and bile acids on staphylococci]. Sytnik IA, Tkachuk NI.Antibiotiki. 1982 Nov;27(11):823-7. Russian. PMID: 7181465 </br>7:[Aspects of urinary furagin excretion in rabbits]. Paberza MIa, Gilev AP, Parinov VIa.Farmatsiia. 1980 May-Jun;29(3):66-7. Russian. No abstract available. PMID: 7409226 </br>8:[Express acidimetric method of determining soluble furagin]. Suprun PP.Farm Zh. 1980;(1):71-2. Ukrainian. No abstract available. PMID: 7371820 </br>9:Pharmacokinetics of furagin, a new nitrofurantoin congener, on human volunteers. Männistö P, Karttunen P.Int J Clin Pharmacol Biopharm. 1979 Jun;17(6):264-70. PMID: 468451 </br>10:[Use of furagin in treatment of urinary tract infections]. Mis M, Boian M, Lente I, Shari B, Boda Z.Ter Arkh. 1978;50(2):119-23. Russian. No abstract available. PMID: 25493 |
