For research use only. Not for therapeutic Use.
Furanodiene is a natural terpenoid isolated from Rhizoma Curcumae. Furanodiene plays anti-cancer effects through anti-angiogenesis and inducing ROS production, DNA strand breaks and apoptosis. Furanodiene suppresseed efflux transporter Pgp (P-glycoprotein) function and reduced Pgp protein level[1].
Furanodiene (1.4, 4.1, 12.2 uM; 48 hours) is effective in treating human JF 305 pancreatic cancer cells and MCF-7 breast cancer cells xenotranplanted into the zebrafish[1].
Furanodiene has no effect on Pgp related gene (MDR1) expression[1].
| Catalog Number | M008375 |
| CAS Number | 19912-61-9 |
| Synonyms | (5E,9Z)-3,6,10-trimethyl-4,7,8,11-tetrahydrocyclodeca[b]furan |
| Molecular Formula | C15H20O |
| Purity | ≥95% |
| InChI | InChI=1S/C15H20O/c1-11-5-4-6-12(2)9-15-14(8-7-11)13(3)10-16-15/h6-7,10H,4-5,8-9H2,1-3H3/b11-7+,12-6- |
| InChIKey | VMDXHYHOJPKFEK-RZWYOFBOSA-N |
| SMILES | CC1=CCC2=C(CC(=CCC1)C)OC=C2C |
| Reference | [1]. Xiao-Yu Zhu, et al. Sensitization and synergistic anti-cancer effects of Furanodiene identified in zebrafish models. Sci Rep. 2019 Mar 14;9(1):4541. |
