Furanodienone

• CAT Number: I017934
• CAS Number: 24268-41-5
• Molecular Formula: C₁₅H₁₈O₂
• Molecular Weight: 230.3
• Purity: ≥95%
• Target: Apoptosis

Furanodienone (CAT: I017934) is a major bioactive constituent derived from Rhizoma Curcumae. It has been found to induce apoptosis in various cancer cell lines. In vitro, studies have shown that furanodienone exhibits dose-dependent inhibitory effects on cell viability, with IC50 values ranging from 56.4 μM to 573.8 μM depending on the cell line and duration of treatment. Furanodienone treatment also leads to an increase in caspase-9 and caspase-3 activity, indicating activation of apoptotic pathways. The apoptotic rates are significantly increased in both RKO and HT-29 cells in a dose-dependent manner. These findings suggest that furanodienone has the potential as an apoptosis-inducing compound with anticancer properties.

Reference

[1]. Li YW, et al. Furanodienone induces cell cycle arrest and apoptosis by suppressing EGFR/HER2 signaling in HER2-overexpressing human breast cancer cells. Cancer Chemother Pharmacol. 2011 Nov;68(5):1315-23.