Furosine

• CAT Number: I027856
• CAS Number: 19746-33-9
• Molecular Formula: C12H18N2O4
• Molecular Weight: 254.28
• Purity: ≥95%
• Synonyms: Furosine
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).
• IUPAC Name: (2S)-2-amino-6-[[2-(furan-2-yl)-2-oxoethyl]amino]hexanoic acid
• InChI: InChI=1S/C12H18N2O4/c13-9(12(16)17)4-1-2-6-14-8-10(15)11-5-3-7-18-11/h3,5,7,9,14H,1-2,4,6,8,13H2,(H,16,17)/t9-/m0/s1
• InChIKey: YQHPCDPFXQXCMV-VIFPVBQESA-N
• SMILES: C1=COC(=C1)C(=O)CNCCCC[C@@H](C(=O)O)N

Furosine (Cat.No:I027856), also known as ε-N-(2-furoylmethyl)-L-lysine, is a Maillard reaction product formed during heat treatment or processing of food. It is commonly used as an indicator for assessing the extent of protein degradation and the degree of heat-induced damage in food products. Furosine levels can provide insights into the quality and nutritional value of processed foods.

Reference

1. Li H, Wang B, Yang H, Wang Y, Xing L, Chen W, Wang J, Zheng N. Furosine Posed Toxic Effects on Primary Sertoli Cells through Regulating Cep55/NF-κB/PI3K/Akt/FOX01/TNF-α Pathway. Int J Mol Sci. 2019 Jul 30;20(15):3716. doi: 10.3390/ijms20153716. PMID: 31366014; PMCID: PMC6696181.
2. Li H, Wang Y, Yang H, Zhang Y, Xing L, Wang J, Zheng N. Furosine, a Maillard Reaction Product, Triggers Necroptosis in Hepatocytes by Regulating the RIPK1/RIPK3/MLKL Pathway. Int J Mol Sci. 2019 May 14;20(10):2388. doi: 10.3390/ijms20102388. PMID: 31091743; PMCID: PMC6566718.
3. Saeed Y, Wang JQ, Zheng N. Furosine induces DNA damage and cell death in selected human cell lines: a strong toxicant to kidney Hek-293 cells. Food Sci Biotechnol. 2017 Aug 30;26(4):1093-1101. doi: 10.1007/s10068-017-0131-1. PMID: 30263641; PMCID: PMC6049533.