Furowanin A

• CAT Number: R064456
• CAS Number: 911004-72-3
• Molecular Formula: C25H26O7
• Molecular Weight: 438.476
• Purity: ≥95%
• Target: Stem Cell/Wnt
• Storage: -20°C
• IUPAC Name: 6-(3,4-dihydroxyphenyl)-4-hydroxy-2-(2-hydroxypropan-2-yl)-9-(3-methylbut-2-enyl)-2,3-dihydrofuro[3,2-g]chromen-5-one
• InChI: InChI=1S/C25H26O7/c1-12(2)5-7-14-23-15(10-19(32-23)25(3,4)30)21(28)20-22(29)16(11-31-24(14)20)13-6-8-17(26)18(27)9-13/h5-6,8-9,11,19,26-28,30H,7,10H2,1-4H3
• InChIKey: NMEQUFXTRAXRGN-UHFFFAOYSA-N
• SMILES: CC(=CCC1=C2C(=C(C3=C1OC=C(C3=O)C4=CC(=C(C=C4)O)O)O)CC(O2)C(C)(C)O)C

Furowanin A (CAS 911004-72-3) is a natural flavonoid found in the herbs of Derris robusta. Furowanin A exhibits significant cytotoxicity against HL-60 cells.

Reference

1.Ito, Chihiro, et al. "Induction of apoptosis by isoflavonoids from the leaves of Millettia taiwaniana in human leukemia HL-60 cells." Planta medica 72.05 (2006): 424-429.
2.Zhao, Jinxia, Junhua Xu, and Jing Lv. "Identification of profilin 1 as the primary target for the anti-cancer activities of Furowanin A in colorectal cancer." Pharmacological Reports 71.5 (2019): 940-949.