For research use only. Not for therapeutic Use.
Fuziline is a alkaloid isolated from the lateral roots of Aconitum carmichaelii[1].
Fuziline shows activity against pentobarbital sodiuminduced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability[1].
Fuziline exhibits the mean half-life of 5.93 hours, 6.13 hours and 5.12 hours for 14 mg/kg, 2 4 mg/kg and 4 mg/kg, respectively, by oral administration in rat[2].
| Catalog Number | R035324 |
| CAS Number | 80665-72-1 |
| Synonyms | (2R,3R,4S,5S,6R,7S,8R,13S,16S,17R,18R)-11-ethyl-6,18-dimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecane-4,7,8,16-tetrol |
| Molecular Formula | C24H39NO7 |
| Purity | ≥95% |
| InChI | InChI=1S/C24H39NO7/c1-5-25-9-22(10-30-2)7-6-13(26)23-12-8-11-16(27)14(12)24(29,21(28)17(11)31-3)15(20(23)25)18(32-4)19(22)23/h11-21,26-29H,5-10H2,1-4H3/t11-,12+,13-,14+,15?,16-,17+,18-,19+,20?,21-,22-,23?,24+/m0/s1 |
| InChIKey | FPECZWKKKKZPPP-WFAXMRCRSA-N |
| SMILES | CCN1CC2(CCC(C34C2C(C(C31)C5(C6C4CC(C6O)C(C5O)OC)O)OC)O)COC |
| Reference | [1]. Xiong L, et al. Alkaloids isolated from the lateral root of Aconitum carmichaelii. Molecules. 2012 Aug 20;17(8):9939-46. [2]. Li YX, et al. Development and validation of a UHPLC-qTOF-MS method for quantification of fuziline in rat plasma and its application in a pharmacokinetic study. Biomed Chromatogr. 2014 Dec;28(12):1707-13. |
