For research use only. Not for therapeutic Use.
G-1 (CAT: I010784) is a synthetic compound and a potent agonist of the G-protein-coupled estrogen receptor 1 (GPER). GPER, also known as GPR30, is a membrane receptor that mediates estrogen signaling in various tissues and organs. G-1 specifically activates GPER without binding to other estrogen receptors, such as ERα and ERβ. This selective activation of GPER by G-1 leads to downstream cellular responses involved in hormone regulation, cell proliferation, and other physiological processes. G-1 has been studied for its potential therapeutic applications, particularly in the field of cancer research, where GPER activation may influence tumor growth, metastasis, and hormone-related cancers.
| Catalog Number | I010784 |
| CAS Number | 881639-98-1 |
| Synonyms | (±)-1-[(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]- ethanone |
| Molecular Formula | C21H18BrNO3 |
| Purity | ≥95% |
| Target | Estrogen Receptor/ERR |
| Solubility | Soluble to 100 mM in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | 1-[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]ethanone |
| InChI | InChI=1S/C21H18BrNO3/c1-11(24)12-5-6-18-15(7-12)13-3-2-4-14(13)21(23-18)16-8-19-20(9-17(16)22)26-10-25-19/h2-3,5-9,13-14,21,23H,4,10H2,1H3 |
| InChIKey | VHSVKVWHYFBIFJ-UHFFFAOYSA-N |
| SMILES | CC(=O)C1=CC2=C(C=C1)NC(C3C2C=CC3)C4=CC5=C(C=C4Br)OCO5 |
| Reference | Bologa, C. G., Revankar, C. M., Young, S. M., Edwards, B. S., Arterburn, J. B., Kiselyov, A. S., … & Prossnitz, E. R. (2006). Virtual and biomolecular screening converge on a selective agonist for GPR30. Nature chemical biology,2(4), 207-212. |
