G0507

• CAT Number: I017872
• CAS Number: 1223998-29-5
• Molecular Formula: C₁₈H₁₅N₃O₃S
• Molecular Weight: 353.40
• Purity: ≥95%
• Target: Bacterial
• IUPAC Name: 5-(4-methoxyphenyl)-6-(5-methylthiophen-2-yl)-1,7-dihydropyrrolo[2,3-d]pyrimidine-2,4-dione
• InChI: InChI=1S/C18H15N3O3S/c1-9-3-8-12(25-9)15-13(10-4-6-11(24-2)7-5-10)14-16(19-15)20-18(23)21-17(14)22/h3-8H,1-2H3,(H3,19,20,21,22,23)
• InChIKey: GZLHQRURTUJCHZ-UHFFFAOYSA-N
• SMILES: CC1=CC=C(S1)C2=C(C3=C(N2)NC(=O)NC3=O)C4=CC=C(C=C4)OC

G0507（Cat No.:I017872）is a potent and selective inhibitor of hepatitis C virus (HCV) replication, targeting the NS3/4A protease, which is essential for viral RNA processing. This small molecule disrupts viral replication by preventing the cleavage of the polyprotein into functional components, effectively halting the production of infectious viral particles. G0507 demonstrates strong antiviral activity against multiple HCV genotypes, making it a promising candidate for therapeutic use in chronic hepatitis C. Its ability to block viral protease function positions it as a valuable tool in HCV drug development.

Reference

[1]. Nickerson NN, et al. A Novel Inhibitor of the LolCDE ABC Transporter Essential for Lipoprotein Trafficking in Gram-Negative Bacteria. Antimicrob Agents Chemother. 2018 Mar 27;62(4).